Research progress on effects of biosynthetic selenium nanoparticles on intestinal mucosal immune function and microbial homeostasis

  • XU Dandan ,
  • CHENG Yirui ,
  • HUANG Shimeng ,
  • LIU Shuang ,
  • WANG Fenghuan
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  • 1(Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University), Ministry of Education, Beijing 100048, China)
    2(National Key Laboratory of Livestock and Poultry Nutrition and Feeding, College of Animal Science and Technology, China Agricutural University, Beijing 100193, China)
    3(Jilin Jinziyuan Biotechnology Co.Ltd., Siping 136400, China)

Received date: 2024-06-07

  Revised date: 2024-07-23

  Online published: 2025-06-11

Abstract

Selenium nanoparticles have been widely used in functional foods and other fields due to their good biocompatibility, bioavailability, and low toxicity.This article reviewed the biosynthesis methods of selenium nanoparticles and research progresses in regulating intestinal mucosal immune function and maintaining intestinal microbiota homeostasis.Selenium nanoparticles could alleviate intestinal injury by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and its downstream genes.They exerted anti-inflammatory effects by inhibiting the Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) pathway.In the future, researchers could further explore the probiotic mechanism of biosynthesis of selenium nanoparticles, leverage the synergistic effect of probiotics and selenium nanoparticles, and achieve more precise and efficient probiotic effects, based on the foundations provided by this study.

Cite this article

XU Dandan , CHENG Yirui , HUANG Shimeng , LIU Shuang , WANG Fenghuan . Research progress on effects of biosynthetic selenium nanoparticles on intestinal mucosal immune function and microbial homeostasis[J]. Food and Fermentation Industries, 2025 , 51(10) : 368 -375 . DOI: 10.13995/j.cnki.11-1802/ts.040130

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