Please wait a minute...
Food and Fermentation Industries    2022, Vol. 48 Issue (20) : 307-313     DOI: 10.13995/j.cnki.11-1802/ts.030098
Research progress on the nutritional and functional components of blueberry leaves and their biological activities
CAI Shaoyi, WANG Qin, TAO Liang*
(Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510000, China)
Download: PDF(1472 KB)   HTML 
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract  Blueberry is a kind of medicinal and edible plant. Blueberry resources are widely distributed and with high production in China. Blueberry leaves are rich in bioactive substances such as polyphenols (flavonoids, chlorogenic acid, proanthocyanidins, etc.) and polysaccharides. Blueberry leaves have a series of significant pharmacological effects such as anti-oxidation, lowering blood sugar and blood fat, anti-tumor, anti-bacterial, anti-inflammatory as well as improving cardiovascular and cerebrovascular fitness. By introducing the nutritious and medicinal ingredients of blueberry leaves and summarizing its research progress and application potential, it provides ideas for the development of blueberry leaves as a green resource.
Keywords blueberry leaves      polyphenols      chlorogenic acid      anthocyanin      flavonoids      medicinal value     
Issue Date: 18 November 2022
URL:     OR
[1] 严红光, 李丽, 杨芩, 等.蓝莓叶多酚及抗氧化研究[J].食品科技, 2018, 43(10):285-288.YAN H G, LI L, YANG Q, et al.Phenolic compounds and antioxidant activity of blueberry leaf[J].Food Science and Technology, 2018, 43(10):285-288.
[2] 陈昌琳, 阳翠, 董顺文, 等.蓝莓叶综合利用的研究进展[J].食品工业, 2019, 40(7):226-229.CHEN C L, YANG C, DONG S W, et al.Comprehensive utilization of blueberry leaves:A review[J].The Food Industry, 2019, 40(7):226-229.
[3] 钱爱萍, 林虬, 颜孙安, 等.乌饭树叶蛋白质中氨基酸含量及营养价值评价[J].福建农业学报, 2008, 23(3):306-309.QIAN A P, LIN Q, YAN S A, et al.Amino acids in Vacinium bracteatum leaves and their nutritional evaluation[J].Fujian Journal of Agricultural Sciences, 2008, 23(3):306-309.
[4] 马田田. 笃斯越桔叶营养成分分析[J].特产研究, 2001, 23(1):19-21.MA T T.The analysis or the nutritive constitrents in the leaf of Vaccinium uliginosum L[J].Special Wild Economic Animal and Plant Research, 2001, 23(1):19-21.
[5] 王广仪, 孟献梅, 赵祥大, 等.乌饭树叶中20种微宏量元素的原子发射和原子吸收光谱分析[J].微量元素与健康研究, 1997, 14(2):31-32.WANG G Y, MENG X M, ZHAO X D, et al.Atomic emission and atomic absorption spectra analysis of 20 micromacro elements in leaves of Vacinium bracteatum[J]. Studies of Trace Elements and Health, 1997,14(2): 31-32.
[6] FERLEMI A V, MERMIGKI P G, MAKRI O E, et al.Cerebral area differential redox response of neonatal rats to selenite-induced oxidative stress and to concurrent administration of highbush blueberry leaf polyphenols[J].Neurochemical Research, 2015, 40(11):2 280-2 292.
[7] NAVEED M, HEJAZI V, ABBAS M, et al.Chlorogenic acid (CGA):A pharmacological review and call for further research[J].Biomedicine & Pharmacotherapy, 2018, 97:67-74.
[8] RIIHINEN K, JAAKOLA L, KÄRENLAMPI S, et al.Organ-specific distribution of phenolic compounds in bilberry (Vaccinium myrtillus) and ‘northblue' blueberry (Vaccinium corymbosum x V.angustifolium)[J].Food Chemistry, 2008, 110(1):156-160.
[9] 李晓英, 薛梅, 樊汶樵, 等.不同干燥方式对蓝莓叶中酚类物质及其抗氧化活性的影响[J].中国农业科学, 2018, 51(13):2 570-2 578.LI X Y, XUE M, FAN W Q, et al.Analysis of phenolic compounds and antioxidant activities of blueberry leaves from different drying methods[J].Scientia Agricultura Sinica, 2018, 51(13):2 570-2 578.
[10] 吴桂玲, 邓维先, 贺银菊.蓝莓叶黄酮类化合物研究进展[J].粮食与油脂, 2021, 34(6):6-9.WU G L, DENG W X, HE Y J.Research progress of flavonoids from blueberry leaves[J].Cereals & Oils, 2021, 34(6):6-9.
[11] WANG L J, WU J, WANG H X, et al.Composition of phenolic compounds and antioxidant activity in the leaves of blueberry cultivars[J].Journal of Functional Foods, 2015, 16:295-304.
[12] SONG Y, HUANG L L, YU J F.Effects of blueberry anthocyanins on retinal oxidative stress and inflammation in diabetes through Nrf2/HO-1 signaling[J].Journal of Neuroimmunology, 2016, 301:1-6.
[13] 徐啟馨. 乌饭树树叶多糖的提取、理化性质及抗氧化性研究[D].合肥:合肥工业大学, 2017.XU Q X.Preparation, physicochemical properties and antioxidant activities of polysaccharides from Vaccinium bracteatum Thunb.leaves[D].Hefei:Hefei University of Technology, 2017.
[14] 罗康龙, 蒋向辉.蓝莓叶中多糖提取工艺的研究[J].山东化工, 2017, 46(19):27-28, 30.LUO K L, JIANG X H.Study on extraction technology of polysaccharides from blueberry[J].Shandong Chemical Industry, 2017, 46(19):27-28, 30.
[15] LIU F H, CHENG X H, LIU W G, et al.Study on the extraction of polyphenols from blueberry leaves and their antioxidant properties[J].E3S Web of Conferences, 2021, 251:02059.
[16] EHLENFELDT M K, PRIOR R L.Oxygen radical absorbance capacity (ORAC) and phenolic and anthocyanin concentrations in fruit and leaf tissues of highbush blueberry[J].Journal of Agricultural and Food Chemistry, 2001, 49(5):2 222-2 227.
[17] MASTSUO Y, FUJITA Y, OHNISHI S, et al.Chemical constituents of the leaves of rabbiteye blueberry (Vaccinium ashei) and characterisation of polymeric proanthocyanidins containing phenylpropanoid units and A-type linkages[J].Food Chemistry, 2010, 121(4):1 073-1 079.
[18] BIANCA-EUGENIA Š, LAVINIA F C, FLORICUT,A R, et al.The chemical and biological profiles of leaves from commercial blueberry varieties[J].Plants (Basel, Switzerland), 2020, 9(9):1193.
[19] ROUTRAY W, ORSAT V.Variation of phenolic profile and antioxidant activity of North American highbush blueberry leaves with variation of time of harvest and cultivar[J].Industrial Crops and Products, 2014, 62:147-155.
[20] 黄婧, 赵青, 周鹏, 等.不同产地乌饭树叶中黄酮成分含量差异研究[J].江苏林业科技, 2020, 47(4):8-12, 21.HUANG J, ZHAO Q, ZHOU P, et al.Analysis of flavonoids in the leaves of Vaccinium bracteatum Thunb.from different regions[J].Journal of Jiangsu Forestry Science & Technology, 2020, 47(4):8-12, 21.
[21] LI C Y, FENG J, HUANG W Y, et al.Composition of polyphenols and antioxidant activity of rabbiteye blueberry (Vaccinium ashei) in Nanjing[J].Journal of Agricultural and Food Chemistry, 2013, 61(3):523-531.
[22] 武玉祥, 万合锋, 封天洪, 等.蓝莓叶内芦丁含量的检测[J].安徽农业科学, 2019, 47(13):188-191.WU Y X, WAN H F, FENG T H, et al.Detecting rutin content in blueberry leaves[J].Journal of Anhui Agricultural Sciences, 2019, 47(13):188-191.
[23] 刘静. 蓝莓叶片原花青素的提取、分离及抗氧化活性研究[D].福州:福建农林大学, 2014.LIU J.Study on extration, separation process and antioxidan activity of procy anidins from blueberry(Vaccinium ashei Reade) leaves[D].Fuzhou:Fujian Agriculture and Forestry University, 2014.
[24] 战伟伟, 司振军, 王超萍, 等.蓝莓叶原花青素提取工艺研究[J].粮食与油脂, 2010, 23(6):39-42.ZHAN W W, SI Z J, WANG C P, et al.Study on extracting and separation technology of proanthocyanidins from blueberry leaves[J].Cereals & Oils, 2010, 23(6):39-42.
[25] 刘建祥, 杜丽亭, 李芋娇, 等.蓝莓叶超声提取黄酮类化合物抗氧化活性的研究[J].粮食与油脂, 2018, 31(8):75-78.LIU J X, DU L T, LI Y J, et al.Study on antioxidant activities of total flavonoid from blueberry leaves extracted by ultrasonic[J].Cereals & Oils, 2018, 31(8):75-78.
[26] PILJAC-ZEGARAC J, BELSCAK A, PILJAC A.Antioxidant capacity and polyphenolic content of blueberry (Vaccinium corymbosum L.) leaf infusions[J].Journal of Medicinal Food, 2009, 12(3):608-614.
[27] 焦豪妍, 许梦怡, 师大智, 等.蓝莓叶总黄酮对LPS/D-GalN诱导小鼠急性肝损伤的保护作用[J].食品研究与开发, 2020, 41(17):1-6.JIAO H Y, XU M Y, SHI D Z, et al.Efffect of flavonoids in blueberry leaf(Vaccinium corymbosum L.)on hepatoprotective and LPS/D-GalN-induced acute liver injury in mice[J].Food Research and Development, 2020, 41(17):1-6.
[28] WANG L, ZHANG X T, ZHANG H Y, et al.Effect of Vaccinium bracteatum Thunb.leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice[J].Journal of Ethnopharmacology, 2010, 130(3):465-469.
[29] 王立, 张雪彤, 章海燕, 等.乌饭树树叶水提取物改善糖尿病小鼠血糖和血脂水平的研究[J].食品工业科技, 2012, 33(5):363-365.WANG L, ZHANG X T, ZHANG H Y, et al.Effect of Vaccinium bracteatum Thunb.leaves aqueous extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice[J].Science and Technology of Food Industry, 2012, 33(5):363-365.
[30] 叶俊丽, 梁韬.乌饭树叶黄酮对糖尿病小鼠胰岛形态和功能的影响[J].中国医院药学杂志, 2020, 40(12):1 345-1 348;1 389.YE J L, LIANG T.Effects of Vaccinium bracteatum Thunb.leaves flavonoids on islet morphology and function in diabetic mice[J].Chinese Journal of Hospital Pharmacy, 2020, 40(12):1 345-1 348;1 389.
[31] TAKÁCS I, SZEKERES A, TAKÁCS Á, et al.Wild strawberry, blackberry, and blueberry leaf extracts alleviate starch-induced hyperglycemia in prediabetic and diabetic mice[J].Planta Medica, 2020, 86(11):790-799.
[32] 包正宇, 樊铭聪, 李言, 等.乌饭树树叶蓝黑色素对α-葡萄糖苷酶的抑制活性研究[J].食品与机械, 2021, 37(7):165-170;76.BAO Z Y, FAN M C, LI Y, et al.Study on the α-glucosidase inhibition of the dark blue pigment from the leaves of Vaccinium bracteatum Thunb[J].Food & Machinery, 2021, 37(7):165-170;176.
[33] NAGAO K, HIGA K, SHIROUCHI B, et al.Effect of Vaccinium ashei Reade leaves on lipid metabolism in otsuka long-evans tokushima fatty rats[J].Bioscience, Biotechnology, and Biochemistry, 2008, 72(6):1 619-1 622.
[34] LI Z, ZHANG H X,LI Y, et al.Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense[J].Phytomedicine, 2020, 69:153209.
[35] 王雪竹, 郭晓君, 赵光远.蓝莓叶总黄酮降血脂作用的研究[J].医药论坛杂志, 2016, 37(5):15-16.WANG X Z, GUO X J, ZHAO G Y.Study on reducing blood lipids of flavonoids from blueberry leaves[J].Journal of Medical Forum, 2016, 37(5):15-16.
[36] SHOJI K, YAMASAKI M, KUNITAKE H.Effects of dietary blueberry (Vaccinium ashei Reade) leaves on mildly postprandial hypertriglyceridemia[J].Journal of Oleo Science, 2020, 69(2):143-151.
[37] LI K, MA C Y, JIAN T C, et al.Making good use of the byproducts of cultivation:Green synthesis and antibacterial effects of silver nanoparticles using the leaf extract of blueberry[J].Journal of Food Science and Technology, 2017, 54(11):3 569-3 576.
[38] 王亚丽, 李颖畅, 马春颖, 等.蓝莓叶多酚提取物对3种细菌的抑菌活性[J].食品与发酵工业, 2015, 41(3):163-167.WANG Y L, LI Y C, MA C Y, et al.Study on antimicrobial activity of blueberry leaf polyphenol against three microorganisms[J].Food and Fermentation Industries, 2015, 41(3):163-167.
[39] SILVA S, COSTA E M, PEREIRA M F, et al.Evaluation of the antimicrobial activity of aqueous extracts from dry Vaccinium corymbosum extracts upon food microorganism[J].Food Control, 2013, 34(2):645-650.
[40] PERVIN M, HASNAT M A, LIM B O.Antibacterial and antioxidant activities of Vaccinium corymbosum L. leaf extract[J].Asian Pacific Journal of Tropical Disease, 2013, 3(6):444-453.
[41] KOPUSTINSKIENE D M, JAKSTAS V, SAVICKAS A, et al.Flavonoids as anticancer agents[J].Nutrients, 2020, 12(2):457.
[42] 余清. 乌饭树叶中黄酮等有效成分分析及抗肿瘤作用研究[D].福州:福建农林大学, 2008.YU Q.Studies on flavonoids effective components in Vaccinium bracteatum Thunb. leaves and function of anti-tumor[D].Fuzhou:Fujian Agriculture and Forestry University, 2008.
[43] SKUPIEN′ K, OSZMIAN′SKI J, KOSTRZEWA-NOWAK D, et al.In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells[J].Cancer letters, 2006, 236(2):282-91.
[44] KAI H, UESAWA Y, KUNITAKE H, et al.Direct-injection electron ionization-mass spectrometry metabolomics method for analyzing blueberry leaf metabolites that inhibit adult t-cell leukemia proliferation[J].Planta Medica, 2019, 85(01):81-87.
[45] 王立, 张雪彤, 姚惠源.乌饭树树叶及其提取物对视网膜光损伤的保护作用[J].西安交通大学学报(医学版), 2006(3):284-287;303.WANG L, ZHANG X T, YAO H Y, et al.The protective effect of Vaccinium bracteatum Thumb. leaves and the extract against light injury of retina[J].Journal of Xi′an Jiaotong University (Medical Sciences), 2006,27(3):284-287;303.
[46] 张雪彤, 王立.乌饭树提取物对兔眼视网膜电流图的影响[J].苏州大学学报(医学版), 2006,26(6):1 092-1 093;1 095.ZHANG X T, WANG L.Effect of Vaccinium bracteatum thunb. extract on retinal electrogram in rabbit eyes[J].Suzhou University Journal of Medical Science, 2006,26(6):1 092-1 093;1 095.
[47] JEONG H R, JO Y N, JEONG J H, et al.Blueberry (Vaccinium virgatum) leaf extracts protect against α-induced cytotoxicity and cognitive impairment[J].Journal of Medicinal Food, 2013, 16(11):968-976.
[48] LY C, FERRIER J, GAUDET J, et al.Vaccinium angustifolium (lowbush blueberry) leaf extract increases extravillous trophoblast cell migration and invasion in vitro[J].Phytotherapy Research, 2018, 32(4):705-714.
[49] SHI D Z, XU M Y, REN M Y, et al.Immunomodulatory effect of flavonoids of blueberry (Vaccinium corymbosum L.) leaves via the nf-κβ signal pathway in LPS-stimulated RAW 264.7 cells[J].Journal of Immunology Research, 2017, 2017:5476903.
[1] YANG Qi, XIE Chunliang, ZHOU Yingjun, GONG Wenbing, ZHU Zuohua, XU Chao, PENG Yuande. Antioxidant activity in vitro of probiotics fermented blueberry drink[J]. Food and Fermentation Industries, 2022, 48(9): 112-116.
[2] YUAN Maoyi, CUI Xiaowen, YE Fayin, ZHAO Guohua. Effects of steam explosion pretreatment on polyphenol composition, surface structure and antioxidant activity of apple pomace[J]. Food and Fermentation Industries, 2022, 48(7): 179-185.
[3] ZHANG Hongchen, YU Lin, SHI Hui. Effect of mulberry (Morus alba L.) leaf polyphenols on the preservation of fresh-cut lettuce[J]. Food and Fermentation Industries, 2022, 48(7): 195-200.
[4] YE Chen, ZHANG Bao, YAO Xi, XUN Hang, TANG Feng. Variation of mineral elements in the aging process of bamboo liquor[J]. Food and Fermentation Industries, 2022, 48(6): 32-38.
[5] LIAO Xia, WU Zhen, YANG Yong, CHEN Gang, ZHAN Yong. The differentiation of total polyphenols and total flavonoids contents in Gastrodia elata Bl.f.glauca S.Chow extracts using different solvents and their antioxidant capacities[J]. Food and Fermentation Industries, 2022, 48(5): 157-164.
[6] LI Chong, YANG Yue, QIAN Yu, ZHAO Xin. Effect of polyphenols in white tea on kidney injury induced by D-galactose in mice[J]. Food and Fermentation Industries, 2022, 48(4): 226-234.
[7] KONG Qingxin, LUO Limei, HUANG Yechuan, XU Weiping, ZHANG Jingzhou, LIU Bilin, REN Liping. The effect of high pressure on the combination of β-lactoglobulin and polyphenols using molecular dynamic model[J]. Food and Fermentation Industries, 2022, 48(3): 107-114.
[8] FAN Xiaojing, REN Guangyue, DUAN Xu, CAO Weiwei, LI Linlin, YU Zuyan. Effects of different drying methods on physical properties, quality and anthocyanin content of purple potato powder[J]. Food and Fermentation Industries, 2022, 48(21): 160-166.
[9] WEI Jinwen, KONG Xiangying, ZHANG Wei, CAO Hui, YU Qunli, HAN Ling. Effect of broccoli leaf polyphenols-tapioca starch/pectin composite film on the refrigerated mutton[J]. Food and Fermentation Industries, 2022, 48(21): 232-238.
[10] 袁婷婷, 周子艺, 赵吉春, 李富华, 曾凯芳, 明建. The interactions between proteins and anthocyanins based on covalent/ non-covalent binding: A review[J]. Food and Fermentation Industries, 2022, 48(20): 293-299.
[11] 常海军, 熊杰, 周文斌, 伯朝英. Research progress of plant polyphenols regulating meat protein oxidation and its application in meat products[J]. Food and Fermentation Industries, 2022, 48(20): 329-337.
[12] LIANG Ting, LU Yicheng, LIU Tong, GUAN Tong, LI Sen. Polyphenols extraction from two kinds of origins of millet yellow and their protective effects on oxidative injury on nerve cells[J]. Food and Fermentation Industries, 2022, 48(2): 139-143.
[13] QUAN Wenbin, JI Haoyao, MAI Zifeng, WANG Juan. Research advances in the protective effects of anthocyanins on eyes and their mechanisms[J]. Food and Fermentation Industries, 2022, 48(19): 304-312.
[14] ZHU Yansheng, WEI Ming, QIAN Senhe, ZHAO Shiguang. Purification and α-glucosidase inhibitory activity of polyphenols from purple yam[J]. Food and Fermentation Industries, 2022, 48(16): 182-187.
[15] WEI Ziyan, XIE Yong, WANG Mengmeng, CAI Mengsi, TANG Lanlan, LIU Xiong. Effect of ultrafine grinding on the composition and antioxidant activity of phenolic compounds in rice bran[J]. Food and Fermentation Industries, 2022, 48(14): 138-144.
Full text



Copyright © Food and Fermentation Industries, All Rights Reserved.
Powered by Beijing Magtech Co. Ltd