The effect of various ultrasonic parameters including solid-liquid ratio,ultrasonic time,temperature,power and ultrasonic frequency on the yields of narirutin and hesperidin from blood orange peel was studied.The results showed that the effects of the various parameters on the extraction yields of the two flavonoids were significant,the yields of narirutin and hesperidin were increased by 1.5 times and 2 times with the increase of solid-liquid ratio from 1 ∶ 20 to 1 ∶ 40 ; the extraction yields of narirutin and hesperidin were increased by 1.12 times and 1.25 times with the increase of temperature from 31 ℃ to 60 ℃ ; Meanwhile,the yields of narinitin and hesperidin were increased about 1.14 times and 1.34 times with ultrasonic time increasing from 20 min to 60 min.The extraction yields of hesperidin from blood orange peel residue were much higher than that of narirutin.Based on the 80％ methanol as extraction solvent,the optimum ultrasonic conditions were determined as:solid-liquid ratio of 1 ∶ 40 (g:mL),ultrasonic time of 40 min,temperature of 50 ℃,ultrasonic power of 480 W and frequency of 25 kHz.