ObjectiveThis paper mainly studied the in vitro activity and the zebrafish liver protection of the “Taizhi” solid drink, which is developed based on edible Chinese herbals and corn oligopeptide.MethodThe antioxidant activity of this solid drink was determined by Fe3+reducing power and DPPH free radical scavenging ability. The total triglyceride (TG) was used to evaluate the effect of the solid drink in free fatty acids (Oleic acid and palmitic acid)-induced steatosis in HepG2 cells model. The liver protection was investigated via the zebrafish model of liver injury induced by acetaminophen.ConclusionThe results showed that the “Taizhi” solid drink had excellent ability of antioxidation, obvious modulation effect of lipid metabolism, and the function of liver protection on the zebrafish model of liver injury induced by acetaminophen.