In order to further improve Antarctic krill protein processing characteristics, Antarctic krill protein was modified by sodium tripolyphosphate. Firstly, whether the Antarctic krill protein would be phosphorylated was investigated by FT-IR. Then, taking the phosphorylation degree as index, the optimum reaction parameters of Antarctic krill protein phosphorylation were determined by the single and orthogonal experiments. The result suggested that the optimum conditions were protein concentration 22g/L,STP addition of 6.55g/100g蛋白,heating time 1.55?h,pH?9.04,temperature 39.90?℃.Under these conditions, the phosphorylation degree was 41.91?mg/g. Theresult indicate that the use of sodium tripolyphosphate on the Antarctic krill protein phosphorylation is feasible.