Lettuce is a table of popular vegetables such as salad. Fresh-cut lettuce is fresh lettuce by cleaning, processing, packaging and other processes, then transported to the market by refrigerated as ready-to-eat products. This paper is based on the recent studies of fresh-cut lettuce at home and abroad in recent years, the quality changes of lettuce after processing were analyzed, the research status of physical, chemical and biological preservation techniques was summarized. The aim was to provide theoretical references for the fresh-keeping technology of fresh-cut lettuce, especially fresh-cut vegetables.