Dornfelder (DF); Garanior (GA); Merlot (ML);Pinot Noir (PN) and Cabernet Sauvignon (CS) were used as the research objects herein to analyze the diseases resistance; content of phenolic compounds; organoleptic qualities and phenolic compounds of wines to select suitable cutivars for Yangling area. The results showed that the climate condition of Yangling is more suitable for planting middle and late mature grape varieties. Although the fungal disease susceptibility level of medium and late mature varieties was higher than that of early mature varieties; they showed better accumulation of carbohydrates and polyphenols and better sensory quality of wine.