In this experiment, soybean lecithin and cholesterol was used as the membrane materials, through film dispersion and hydration method, using entrapment efficiency as the index, The response surface method was applied to optimize the lycium barbarum polysaccharide liposome preparation technology.The ratio of drug to lipid ratio, membrane material, water temperature were all major factors.Based on the test of three factors and three levels of Box-Benhnken center combination method design, The best conditions were as follows: drug lipid ratio was 32.15, the membrane material ratio was 3.84, water temperature of 43.26 ℃.Under the above conditions, the predicted Entrapment efficiency was 70.77% and the actual entrapment efficiency was 70.10%.The error was 0.95%.The experimental results show that this method has high entrapment efficiency rate and was easy to control.The morphological characteristic of liposomes samples after hydration was reveled under scanning electron microscope.