A method was established for the determination of 8 pesticide residues (carbofuran, demeton(o+s), ethoprophos, methamidophos, phoxim, pymetrozine, phosfolan, isozofos) in instant tea powde r on the basis of QuEChERS combined with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).The sample was extracted by water-acetonitrile and cleaned by magnesium sulfate anhydrous and PSA, and then determined by the highly sensitive HPLC-MS/MS.The HPLC-MS/MS conditions were optimized to complete chromatographic separation of 8 pesticide residues within 10 minutes.The pesticide residues were quantified by matrix-matched external standard method.The calibration curves of different samples showed good linearity within the concentrations of spiked levels, the correlation coefficients (R2) were 0.996 9-0.999 8, the limits of quantification (LOQs) were 0.2-1 μg/kg, and the average recoveries were 61%-118%.The QuEChERS-HPLC-MS/MS method was simple, rapid, sensitive, accurate and was applicable for the determination of multiple pesticide residues in instant tea power simultaneously.