The exposure of naturally occurring mycotoxins affects human health and plays a vital role in cancer initiation and progression.Increasing evidences indicated that exposure to mycotoxin was associated with many diseases.Many mycotoxins have been proved to alter the histone modification status，such epigenetic changes are related to the occurrence and development of many disease.Recently, the mode of mycotoxins epigenetic research has been advanced in research hotspots.However, there is still no study on histone modification of mycotoxin-induced toxicity.In this paper, the effects of several mycotoxins including aflatoxin (AFB1), deoxynivalenol (DON), ochratoxin (OTA), fumonisim B1 (FB1) and T-2 toxin on histone modification，and the involved pathogenic mechanisms were reviewed.This may be helpful for revealing effects of mycotoxin contamination on human healthy and provide a reference for assessment of food safety risk.