Research progress and application of the L-rhamnose isomerase

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  • (State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China)

Online published: 2018-08-02

Abstract

L-Rhamnose isomerase (L-RI) displays a great potential in biological production of various rare sugars because of its broad substrate specificity towards many aldoses and ketoses, including D-psicose and D-allose. The crystal structure of L-RI has been solved recently and its gene has been cloned, sequenced and high-level expressed. L-RI variant improved by molecular modification will be the dominant enzyme for industrial production of D-allose. Recent advances on crystallographic structure analysis and catalytic mechanism of various L-RIs were overviewed. Enzyme properties and application in D-allose production were also provided in detail, and the potential research trend of L-RI was prospected.

Cite this article

.CHEN Jia-jun et al . Research progress and application of the L-rhamnose isomerase[J]. Food and Fermentation Industries, 2018 , 44(6) : 263 -270 . DOI: 10.13995/j.cnki.11-1802/ts.016899

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