Effects of three Lactobacillus plantarum strains on gut microbiota in metabolic syndrome rats

  • ZHU Guang-su ,
  • WANG Gang ,
  • WANG Yuan-yuan ,
  • MA Fang-li ,
  • ZHAO Jian-xin ,
  • ZHANG Hao ,
  • CHEN Wei
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  • 1(School of Food Science and Technology, Jiangnan University, Wuxi 214122, China)
    2(Infinitus (China) Company Ltd., Guangzhou 510623, China)

Received date: 2018-03-02

  Online published: 2018-10-30

Abstract

The effects of three L. plantarum strains from different sources on intestinal microflora in rats with metabolic syndrome induced by high-fat-high-sucrose(HFHS)diet were evaluated. Three L. plantarum strains from different sources were individually administered to rats fed a HFHS diet for 12 weeks. Using commercial probiotic Lactobacillus rhamnose GG as a strain control, faecal samples were collected at the end of the experiment. The microbial diversity and composition were measured by Illumina Miseq Sequencing. L. plantarum CCFM591 significantly increased the abundance and microbial diversity of intestinal microbiota by α diversity analysis. PCoA analysis showed that HFHS diet changed the overall structure of microbial community. L. plantarum supplementation displayed various effects on the recovery of gut microbiota dysbiosis. Metagenomic analysis showed that CCFM591 dramatically decreased the ratio of Firmicutes/Bacteroidetes and Proteobacteria/Bacteroidetes induced by HFHS diet. Supplementation with L. plantarum increased the relative abundance of Lactabacillus, and decreased the abundance of Blautia,Coprococcus,Roseburia and [Ruminococcus] at genus level. L. plantarum CCFM591 showed a strong capacity in regulating the gut microbiota dysbiosis induced by HFHS diet.

Cite this article

ZHU Guang-su , WANG Gang , WANG Yuan-yuan , MA Fang-li , ZHAO Jian-xin , ZHANG Hao , CHEN Wei . Effects of three Lactobacillus plantarum strains on gut microbiota in metabolic syndrome rats[J]. Food and Fermentation Industries, 2018 , 44(9) : 53 -60 . DOI: 10.13995/j.cnki.11-1802/ts.017147

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