Research progress of serralysin and its inhibitor

  • ZHANG Lin-huan ,
  • SUN Mi ,
  • WANG Wei ,
  • SUN Jing-jing ,
  • LIU Jun-zhong ,
  • HAO Jian-hua
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  • 1(Key Laboratory Sustainable Development of Polar Fishery,Ministry of Agriculture and Rural Affairs,The Yellow Sea Fisheries Research Institute of Chinese Academy of Fishery Sciences,Qingdao 266071, China)
    2(College of Food Science & Technology,Shanghai Ocean University,Shanghai 201306, China)
    3(Jiangsu Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resource,Jiangsu 222005, China)

Received date: 2018-05-31

  Online published: 2018-12-25

Abstract

Serralysin belongs to the subfamily of zinc metalloprotease M10B and is secreted by a variety of pathogenic gram-negative bacteria. It is a key virulence factor for some diseases. Serralysin inhibitor is an effective drug for treating these diseases and it can prevent antibiotic resistance in pathogenic bacteria. In this paper, serralysin and its inhibitor were reviewed, respectively. Four complexes of them were briefly described, in order to further understand the mechanism of the secretion of serralysin and to provide reference for designing novel inhibitor drugs.

Cite this article

ZHANG Lin-huan , SUN Mi , WANG Wei , SUN Jing-jing , LIU Jun-zhong , HAO Jian-hua . Research progress of serralysin and its inhibitor[J]. Food and Fermentation Industries, 2018 , 44(11) : 313 -318 . DOI: 10.13995/j.cnki.11-1802/ts.017925

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