Using carboxymethyl modified konjac glucomannan as raw material and bovine serum albumin as the mimic drug, the carboxymethyl konjac glucomannan/sodium alginate sustained microcapsules were prepared via orifice method. By simulating the human environment in vitro, the human digestive juice was formulated to study the drug release properties and mechanism of the carboxymethyl konjac glucomannan/sodium alginate microcapsules. The results showed that the microcapsules were released slowly in 0-5 h, continued to release in 6-9 h, and the release was basically gentle in 10-12 h. The quality of bovine serum albumin had an effect on the release of microcapsules. When the mass of bovine serum albumin was 30.0 mg, The drug release of microcapsules had a good sustained release effect. The model release of microcapsules showed that the Higuchi equation was more suitable for the release of the drug in vitro, and the drug release was mainly composed of Fick diffusion.
FANG Kun
,
LI Jian-bin
,
WEI Qun-shu
,
NIE Hui
,
LIU Pei-hua
,
CHEN Yu
,
JIANG Ning-ning
. Drug-release of carboxymethyl konjac glucomannan-alginate microcapsule in vitro[J]. Food and Fermentation Industries, 2018
, 44(12)
: 86
-91
.
DOI: 10.13995/j.cnki.11-1802/ts.016688
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