[1] 王宝石, 陈坚, 孙福新, 等. 发酵法生产柠檬酸的研究进展 [J]. 食品与发酵工业,2016, 42(9): 251-256.<br />
[2] YIN X, LI J, SHIN H D, et al. Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: advances and prospects [J]. Biotechnology Advances,2015, 33(6): 830-841.<br />
[3] KUFORIJI O, KUBOYE A O, ODUNFA S A. Orange and pineapple wastes as potential substrates for citric acid production [J]. International Journal of Plant Biology,2010, 1(1): e1-e4.<br />
[4] SOCCOL C R, VANDENBERGHE L P S, RODURIGUES C, et al. New perspectives for citric acid production and application [J]. Food Technology & Biotechnology,2006, 44(2): 141-149.<br />
[5] KRULL R, WUCHERPFENNIG T, ESFANDABADI M E, et al. Characterization and control of <i>fungal morphology</i> for improved production performance in biotechnology [J]. Journal of Biotechnology,2013, 163(2): 112-123.<br />
[6] BIZUKOJC M, LEDAKOWICZ S. Morphologically structured model for growth and citric acid accumulation by <i>Aspergillus niger</i> [J]. Enzyme and Microbial Technology,2003, 32(2): 268-281.<br />
[7] POSCH A E, HERWIG C, SPADIUT O. Science-based bioprocess design for filamentous <i>fungi</i> [J]. Trends in Biotechnology,2013, 31(1): 37-44.<br />
[8] PAPAGIANNI M. Fungal morphology and metabolite production in submerged mycelial processes [J]. Biotechnology Advances,2004, 22(3): 189-259. <br />
[9] NIELSEN J. Modelling the morphology of filamentous microorganisms [J]. Trends in Biotechnology,1996, 14(11): 438-443. <br />
[10] EMERSON S. The growth phase in neurospora corresponding to the logarithmic phase in unicellular organisms [J]. Journal of Bacteriology,1950, 60(3): 221-223. <br />
[11] HERBRICH S, GEHDER M, KRULL R, et al. Label-free spatial analysis of free and enzyme-bound NAD(P)H in the presence of high concentrations of melanin [J]. Journal of Fluorescence,2012, 22(1): 349-355. <br />
[12] WARGENAU A, KWADE A. Determination of adhesion between single <i>Aspergillus niger</i> spores in aqueous solutions using an atomic force microscope [J]. Langmuir,2010, 26(13): 11 071-11 076. <br />
[13] FANG T H, KANG S H, HONG Z H, et al. Elasticity and nanomechanical response of <i>Aspergillus niger</i> spores using atomic force microscopy [J]. Micron,2012, 43(2-3): 407-411.<br />
[14] TOUHAMI A, JERICHO M H, BEVERIDGE T J. Atomic force microscopy of cell growth and division in <i>Staphylococcus Aureus </i>[J]. Journal of Bacteriology,2004, 186(11): 3 286-3 295.<br />
[15] ARFSTEN J, LEUPOLD S, BRADTMLLER C, et al. Atomic force microscopy studies on the nanomechanical properties of <i>Saccharomyces Cerevisiae</i> [J]. Colloids & Surfaces B Biointerfaces,2010, 79(1): 284-290.<br />
[16] DYNESEN J, NIELSEN J. Surface hydrophobicity of <i>Aspergillus nidulans</i> conidiospores and its role in pellet formation [J]. Biotechnology Progress,2003, 19(3): 1 049-1 052.<br />
[17] GALLARDO-MORENO A M, GONZLEZ-MARTN M L, PREZ-GIRALDO C, et al. Thermodynamic analysis of growth temperature dependence in the adhesion of <i>Candida Parapsilosis </i>to Polystyrene [J]. Applied and Environmental Microbiology,2002,68(5): 2 610-2 613.<br />
[18] PRIEGNITZ B E, WARGENAU A, BRANDT U, et al. The role of initial spore adhesion in pellet and biofilm formation in <i>Aspergillus niger</i>[J]. Fungal genetics and biology, 2012, 49(1): 30-38.<br />
[19] WARGENAU A, FLEIβNER A, BOLTEN C J, et al. On the origin of the electrostatic surface potential of <i>Aspergillus niger </i>spores in acidic environments [J]. Research in Microbiology,2011, 162(10): 1 011-1 017.<br />
[20] HPFNER T, BLUMA A, RUDOLPH G, et al. A review of non-invasive optical-based image analysis systems for continuous bioprocess monitoring [J]. Bioprocess & Biosystems Engineering,2010, 33(2): 247-256. <br />
[21] LEY I. Assessing resolution and sensitivity in a laser diffraction particle size analyser [J]. American Laboratory, 2000, 32(16):33-38.<br />
[22] GRIMM L H, KELLY S, VLKERDING I I, et al. Influence of mechanical stress and surface interaction on the aggregation of <i>Aspergillus niger </i>Conidia [J]. Biotechnology and bioengineering,2005, 92(7): 879-888.<br />
[23] HILLE A, NEU T R, HEMPEL D C, et al. Oxygen profiles and Biomass distribution in biopellets of <i>Aspergillus niger</i> [J]. Biotechnology and Bioengineering,2005, 92(5): 614-623.<br />
[24] VILLENA G K, FUJIKAWA T, TSUYUMU S, et al. Structural analysis of biofilms and pellets of <i>Aspergillus niger</i> by confocal laser scanning microscopy and cryo scanning electron microscopy [J]. Bioresource Technology,2009, 101(6): 1 920-1 926.<br />
[25] WUCHERPFENNIG T, LAKOWITZ A, KRULL R. Comprehension of viscous morphology—evaluation of fractal and conventional parameters for rheological characterization of <i>Aspergillus niger</i> culture broth [J]. Journal of Biotechnology,2013, 163(2): 124-132. <br />
[26] BIZUKOJC M, LEDAKOWICZ S. A kinetic model to predict biomass content for <i>Aspergillus niger</i> germinating spores in the submerged culture [J]. Process Biochemistry, 2006, 41(5):1 063-1 071.<br />
[27] LIN P J, SCHOLZ A, KRULL R. Effect of volumetric power input by aeration and agitation on pellet morphology and product formation of <i>Aspergillus niger</i> [J]. Biochemical Engineering Journal,2010, 49(2): 213-220.<br />
[28] YANG S, LEWANDOWSKI Z. Measurement of local mass transfer coefficient in biofilms [J]. Biotechnology and Bioengineering,1995, 48(6): 737-744.<br />
[29] HILLE A, NEU T R, HEMPEL D C, et al. Effective diffusivities and mass fluxes in fungal biopellets [J]. Biotechnology and Bioengineering,2009, 103(6): 1 202-1 213.<br />
[30] CUI Y Q, VAN-DER-LANS R, LUYBEN K C A M. Effects of dissolved oxygen tension and mechanical forces on fungal morphology in submerged fermentation [J]. Biotechnology and Bioengineering,1998, 57(4): 409-419.<br />
[31] DE-BEKKER C, VAN-VELUW G J, VINCK A, et al. Heterogeneity of <i>Aspergillus niger</i> microcolonies in liquid shaken cultures [J]. Applied and Environmental Microbiology,2011, 77(4): 1 263-1 267.<br />
[32] LAFLAMME C, VERREAULT D, LAVIGNE S, et al. Autofluorescence as a viability marker for detection of bacterial spores [J]. Frontiers in Bioscience,2005, 10(2): 1 647-1 653.<br />
[33] TUNG J W, HEYDARI K, TIROUVANZIAM R, et al. Modern flow cytometry: A practical approach[J]. Clinics in Laboratory Medicine, 2007, 27(3): 453-468.<br />
[34] BARRY D J, CHAN C, WILLIAMS G A. Morphological quantification of filamentous fungal development using membrane immobilization and automatic image analysis [J]. Journal of Industrial Microbiology & Biotechnology,2009, 36(6): 787-800.<br />
[35] BARRY D J, WILLIAMS G A. Microscopic characterisation of filamentous microbes: Towards fully automated morphological quantification through image analysis [J]. Journal of Microscopy,2011, 244(1): 1-20.<br />
[36] KOWALSKA A, BORUTA T, BIZUKOJ? M. Morphological evolution of various fungal species in the presence and absence of aluminum oxide microparticles: Comparative and quantitative insights into microparticle-enhanced cultivation (MPEC)[J]. MicrobiologyOpen, 2018, 7(5): e603-e619<br />
[37] GRIMM L H, KELLY S, HENGSTLER J, et al. Kinetic studies on the aggregation of <i>Aspergillus niger</i> conidia [J]. Biotechnology and Bioengineering,2004, 87(2): 213-218.<br />
[38] MAINWARING D O, WIEBE M G, ROBSON G D, et al. Effect of pH on hen egg white lysozyme production and evolution of a recombinant strain of <i>Aspergillus niger</i> [J]. Journal of Biotechnology,1999, 75(1): 1-10.<br />
[39] TUCKER K G, KELLY T, DELGRAZIA P, et al. Fully-automatic measurement of mycelial morphology by image analysis [J]. Biotechnology Progress,1992, 8(4): 353-359.<br />
[40] BIZUKOJC M, LEDAKOWICZ S. Physiological, morphological and kinetic aspects of lovastatin biosynthesis by <i>Aspergillus terreus</i> [J]. Biotechnology Journal,2009, 4(5): 647-664.<br />
[41] AMANULLAH A, CHRISTENSEN L H, HANSEN K, et al. Dependence of morphology on agitation intensity in fed-batch cultures of <i>Aspergillus oryzae</i> and its implications for recombinant protein production [J]. Biotechnology and Bioengineering,2002, 77(7): 815-826.<br />
[42] XIN B, XIA Y, ZHANG Y, et al. A feasible method for growing fungal pellets in a column reactor inoculated with mycelium fragments and their application for dye bioaccumulation from aqueous solution [J]. Bioresource Technology,2012, 105: 100-105.<br />
[43] LPEZ J L C, PREZ J A S, SEVILLA J M F, et al. Pellet morphology, culture rheology and lovastatin production in cultures of<i> Aspergillus terreus </i>[J]. Journal of Biotechnology,2005, 116(1): 61-77.<br />
[44] WUCHERPFENNIG T, HESTLER T, KRULL R. Morphology engineering-osmolality and its effect on <i>Aspergillus niger</i> morphology and productivity [J]. Microbial Cell Factories,2011, 10(1): 58-73.<br />
[45] BOBOWICZ-LASSOCISKA T, GRAJEK W. Changes in protein secretion of <i>Aspergillus niger</i> caused by the reduction of the water activity by potassium chloride [J]. Acta biotechnologica,1995, 15(3): 277-287.<br />
[46] FIEDUREK J. Effect of osmotic stress on glucose oxidase production and secretion by <i>Aspergillus niger</i>[J]. Journal of Basic Microbiology: An International Journal on Biochemistry, Physiology, Genetics, Morphology, and Ecology of Microorganisms, 1998, 38(2): 107-112. <br />
[47] WANG B, CHEN J, LI H, et al. Pellet-dispersion strategy to simplify the seed cultivation of <i>Aspergillus niger</i> and optimize citric acid production [J]. Bioprocess and Biosystems Engineering,2016,40(1):45-53. <br />
[48] REN X D, XU Y J, ZENG X, et al. Microparticle-enhanced production of ε-poly-<i>L</i>-lysine in fed-batch fermentation [J]. Rsc Advances,2015, 5(100): 82 138-82 143.<br />
[49] DRIOUCH H, SOMMER B, WITTMANN C. Morphology engineering of <i>Aspergillus niger </i>for improved enzyme production [J]. Biotechnology and Bioengineering,2010, 105(6): 1 058-1 068.<br />
[50] DRIOUCH H, ROTH A, DERSCH P, et al. Optimized bioprocess for production of fructofuranosidase by recombinant <i>Aspergillus niger</i> [J]. Applied Microbiology and Biotechnology,2010, 87(6): 2 011-2 024.<br />
[51] DRIOUCH H, ROTH A, DERSCH P, et al. Filamentous fungi in good shape: Microparticles for tailor-made fungal morphology and enhanced enzyme production [J]. Bioengineered Bugs,2011, 2(2): 100-104.<br />
[52] DRIOUCH H, H NSCH R, WUCHERPFENNIG T, et al. Improved enzyme production by bio-pellets of <i>Aspergillus niger</i> : Targeted morphology engineering using titanate microparticles [J]. Biotechnology and Bioengineering,2012, 109(2): 462-471.<br />
[53] BIZUKOJC M, LEDAKOWICZ S. The morphological and physiological evolution of <i>Aspergillus terreus</i> mycelium in the submerged culture and its relation to the formation of secondary metabolites [J]. World Journal of Microbiology and Biotechnology,2009, 26(1): 41-54.<br />
[54] PAPAGIANNI M. Quantification of the fractal nature of mycelial aggregation in <i>Aspergillus niger</i> submerged cultures [J]. Microbial Cell Factories,2006, 5(1): 1-13.<br />
[55] PAPAGIANNI M, MATTEY M. Morphological development of <i>Aspergillus niger</i> in submerged citric acid fermentation as a function of the spore inoculum level. Application of neural network and cluster analysis for characterization of mycelial morphology [J]. Microbial Cell Factories,2006, 5 (1): 3-15.<br />
[56] PAPAGIANNI M, MATTEY M, KRISTIANSEN B. Morphology and citric acid production of <i>Aspergillus niger</i> PM 1 [J]. Biotechnology Letters,1994, 16(9): 929-934.<br />
[57] PAPAGIANNI M, MATTEY M, KRISTIANSEN B. Citric acid production and morphology of <i>Aspergillus niger </i>as functions of the mixing intensity in a stirred tank and a tubular loop bioreactor [J]. Biochemical Engineering Journal,1998, 2(3): 197-205.<br />
[58] PAPAGIANNI M, MATTEY M, KRISTIANSEN B. Hyphal vacuolation and fragmentation in batch and fed-batch culture of <i>Aspergillus niger </i>and its relation to citric acid production [J]. Process Biochemistry,1999, 35(3-4): 359-366.<br />
[59] PAUL G C, PRIEDE M A, THOMAS C R. Relationship between morphology and citric acid production in submerged <i>Aspergillus niger</i> fermentations [J]. Biochemical Engineering Journal,1999, 3(2): 121-129.<br />
[60] SEICHERT L, UJCOVA E, MUSILKOVA M, et al. Effect of aerationand agitation on the biosynthetic activity of diffusely growing <i>Aspergillus niger</i> [J]. Folia Microbiologica,1982, 27(5): 333-334. <br />
[61] KISSER M, KUBICEK C P, RδHR M. Influence of manganese on morphology and cell wall composition of <i>Aspergillus niger</i> during citric acid fermentation [J]. Archives of Microbiology,1980, 128(1): 26-33.<br />
[62] GδMEZ R, SCHNABEL I, GARRIDO J. Pellet growth and citric acid yield of <i>Aspergillus niger </i>110 [J]. Enzyme and Microbial Technology,1988, 10(3): 188-191. <br />
[63] BELMAR-BEINY M T, THOMAS C R. Morphology and clavulanic acid production of <i>Streptomyces clavuligerus</i>: effect of stirrer speed in batch fermentations [J]. Biotechnology and bioengineering,1991, 37(5): 456-462.