Research progress on enzyme-mediated cyclization of peptides

  • CHENG Xiaozhong ,
  • ZHOU Zhifang ,
  • WU Zhimeng
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  • (Key Laboratory of Carbohydrate Chemistry & Biotechnology, Jiangnan University, Wuxi 214122, China)

Received date: 2018-07-12

  Online published: 2019-02-01

Abstract

Cyclic peptides are thermally and chemically stable. They have good selectivity and enhanced binding affinity towards target biomolecules. They can be used for structure-activity studies and por drug development. In order to further study their structures and functions, preparing cyclic peptides has become an important problem. Up to date, manufacturing cyclic peptides mainly relies on chemical synthesis, which requires fully protected linear peptide substrate and therefore represents a major challenge. Enzyme-mediated cyclization has been developed as a promising strategy due to their extremely powerful ligating ability and excellent selectivity, which can be applied to generate complex cyclic peptides. Herein, recent advances in enzyme-mediated cyclization of peptides were discussed in this review.

Cite this article

CHENG Xiaozhong , ZHOU Zhifang , WU Zhimeng . Research progress on enzyme-mediated cyclization of peptides[J]. Food and Fermentation Industries, 2019 , 45(1) : 229 -235 . DOI: 10.13995/j.cnki.11-1802/ts.018264

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