[1] FRANCIELO V,ROSE MARIE MEINICKE B,JU′LIO CESAR D C,et al.Monascus: a reality on the production and application of microbial pigments [J].Applied Biochemistry and Biotechnology,2016,178(2):211-223.
[2] CLAIRA ARUL A,LAURENT D,WAN AZLINA A.Current perspective of yellowish-orange pigments from microorganisms-a review[J].Journal of Cleaner Production, 2018,180:168-182.
[3] MANIKPRABHUNARSING R,XIAO M,LI W J.Fungal and bacterial pigments: secondary metabolites with wide applications[J].Frontiers in Microbiology,2017,8(1):1 113-1 126.
[4] 石侃,夏枫耿,吴振强.红曲色素发酵生产过程桔霉素控制技术研究进展[J].中国酿造, 2016(4):1-6.
[5] CHEN G,WU Z Q.Production and biological activities of yellow pigments from Monascus fungi[J].World Journal of Microbiology and Biotechnology,2016,32(8):136.
[6] LIU Jiao,ZHOU Youxiang,YI Tao,et al.Identification and role analysis of an intermediate produced by a polygenic mutant of Monascus pigments cluster in Monascus ruber M7[J].Applied Microbiology and Biotechnology,2016,100(16):7 037-7 049.
[7] HUANG Tao,TAN Hailing,CHEN Gong, et al.Rising temperature stimulates the biosynthesis of water-soluble fluorescent yellow pigments and gene expression in Monascus ruber CGMCC10910[J].AMB Express,2017,7(1):134.
[8] CHENG Mingjen,CHAN Hingyuen,WU Mingder,et al.A new dihydroisocoumarin derivative from the extract of the fungus Monascus-fermented rice [J].Chemistry of Natural Compounds,2017,53(5):856-859.
[9] MANCHAND P S,WHALLEYW B,CHEN F C.Isolation and structure of Ankaflavin: a new pigment from Monascus anka[J]. Phytochemistry,1973, 10(12):2 531-2 532.
[10] YONGSMITH B,KRAIRAK S,BAVAVODA R.Production of yellow pigments in submerged culture of a mutant of Monascus spp.[J].Journal of Fermentation and Bioengineering,1994,78:223-228.
[11] SATOK,IWAKAMIS,GODAY,et al.Novel natural colorants from Monascus anka U-1 [J].Heterocycles,1992,34(11):2 057-2 060.
[12] YONGSMITH B,TABLOKA W,YONGMANITCHAI W, et al.Culture conditions for yellow pigment formation by Monascus sp. KB 10 grown on cassava medium[J].World Journal of Microbiology & Biotechnology, 1993, 9(1):85-90.
[13] CHOWDHURYFAIZ H,OKUYAMAE,YAMAZAKIM.A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka[J].Chemical and Pharmaceutical Bulletin,1996,44(8):1 535-1 539.
[14] JONGRUNGRUANGCHOK S,KITTAKOOP P,YONSMITH B, et al.Azaphilone pigments from a yellow mutant of the fungus Monascus kaoliang [J]. Phytochemistry, 2004,65(18):2 569-2 575.
[15] CAMPOY S,RUMBERO A,MARTIN J F,et al.Characterization of an hyperpigmenting mutant of Monascus purpureus IB1: identification of two novel pigment chemical structures [J].Applied Microbiology and Biotechnology,2006,70(4):488-496.
[16] ZHENG Yunquan,XIN Yawen,GUO Yang-hao.Study on the fingerprint profile of Monascus products with HPLC-FD, PAD and MS [J].Food Chemistry,2009,113(2):705-711.
[17] HSU Yawen,HSU Lichuan,LIANG Yuhan, et al. Monaphilones A-C, three new antiproliferative azaphilone derivatives from Monascus purpureus NTU 568 [J].Journal of Agricultural and Food Chemistry,2010,58(14):8 211-8 216.
[18] LI Jinjie,SHANG Xiaoya,LI Lingling,et al.New cytotoxic Azaphilones from Monascu spurpureus-fermented rice (Red Yeast Rice) [J].Molecules,2010,15(3):1 958-1 966.
[19] LORET M O,MOREL S.Isolation and structural characterization of two new metabolites from Monascus [J].Journal of Agricultural and Food Chemistry,2010,58(3):1 800-1 803.
[20] WU Mingder,CHENG Mingjen,YECH Yijen,et al.Monasnicotinates A-D, four new pyridine alkaloids from the fungal strain Monascus pilosus BCRC 38093[J].Molecules, 2011,16(6):4 719-4 727.
[21] CHENG Mingjen,WU Mingder,CHEN Ihsheng,et al.Chemical constituents from the fungus Monascus purpureus and their antifungal activity [J].Phytochemistry Letters, 2011,4(3):372-376.
[22] XIONG Xu, ZHANG Xuehong,WU Zhenqiang,et al.Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution[J].Applied Microbiology and Biotechnology,2015,99(3):1 173-1 180.
[23] RUGBJERG P,NAESBY M,MORTENSEN U H,et al.Reconstruction of the biosynthetic pathway for the core fungal polyketide scaffold rubrofusarin in Saccharomyces cerevisiae [J].Microbial Cell Factories,2013,12:31.
[24] ITO S,SAITOU T,IMAHORI H,et al.Fabrication of dye-sensitized solar cells using natural dye for food pigment: Monascus yellow [J].Energy & Environmental Science,2010,3(7):905.
[25] 中华人民共和国国家卫生和计划生育委员会. GB 1886.66—2015 食品安全国家标准食品添加剂红曲黄色素[S]. 北京:中国标准出版社, 2015.
[26] 苏金为,甘纯玑,吕日新. 水溶性红曲黄色素的制备[J]. 中国食品学报, 2002, 2(1):8-11.
[27] YANG Haihua,LI Jian,WANG Yuan,et al.Identification of water-soluble Monascus yellow pigments using HPLC-PAD-ELSD, high-resolution ESI-MS, and MS-MS [J].Food Chemistry,2018,245:536-541.
[28] WANG Meihua,HUANG Tao,CHEN Gong,et al.Production of water-soluble yellow pigments via high glucose stress fermentation of Monascus ruber CGMCC 10910 [J].Applied Microbiology and Biotechnology,2017,101(8): 3 121-3 130.
[29] 张庆庆,张帝,汤文晶,等.水溶性和醇溶性红曲色素的光稳定性[J].食品科学,2015(1):94-98.
[30] 杨玲,江丹,周波,等. 红曲黄色素的稳定性及提高光稳定性方法研究[J]. 现代食品科技, 2008(11):1124-1127.
[31] 杨强,王成涛.红曲黄色素的稳定性研究[J].食品工业,2016(3):38-40.
[32] 苏金为,周碧青,彭时尧,等.水溶性红曲黄色素的表征及其稳定性[J].天然产物研究与开发,1999(4):57-61.
[33] 容艳筠,伍剑聪,陈锡堂,等. 红曲黄色素的性质及其在肉制品中的应用研究[J].肉类工业,2015(5):43-46.
[34] LEE Chunlin,PAN Tzuming.Development of Monascus fermentation technology for high hypolipidemic effect[J].Applied Microbiology and Biotechnology,2012,94(6):1 449-1 459.
[35] YANG Tao,LIU Junwen,LUO Feijun,et al.Anticancer properties of Monascus metabolites[J].Anti-Cancer Drugs,2014,25(7):735-744.
[36] LIN Chihhui,LIN Tzuhsing,PAN Tzuming.Alleviation of metabolic syndrome by monascin and ankaflavin: the perspective of Monascus functional foods[J].Food & Function,2017,8(6):2 102-2 109.
[37] ZHENG Yunquan,PAN Qisheng,MO Liuda,et al.Monascus pigment rubropunctatin derivative FZUH reduces Aβ(1-42)-induced neurotoxicity in Neuro-2A cells[J].RSC Advances,2018(8):17 389-17 398.
[38] HSU Weihsuan,CHEN Tinghung,LEE Baohong,et al.Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice[J].Food and Chemical Toxicology,2014,64:94-103.
[39] CHANG Yuying,HSU Weihsuan,PAN Tzuming.Monascus secondary metabolites monascin and ankaflavin inhibit activation of RBL-2H3 cells[J].Journal of Agricultural and Food Chemistry,2014,63(1):192-199.
[40] LEE Baohong,HSU Weihsuan,LIAO Tehan,et al.The Monascus metabolite monascin against TNF-α-induced insulin resistance via suppressing PPAR-γ phosphorylation in C2C12 myotubes [J].Food and Chemical Toxicology,2011,49(10):2 609-2 617.
[41] LIN Chihpei,LIN Yunlin,HUANG PoHsun,et al.Inhibition of endothelial adhesion molecule expression by Monascus purpureus-fermented rice metabolites, monacolin K, ankaflavin, and monascin[J].Journal of the Science of Food and Agriculture,2011,91(10):1 751-1 758.
[42] AKIHISA T,TOKUDAB H,UKIYAA M.Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (Red-Mold Rice)[J].Chemistry & biodiversity,2005,10(2):1 305-1 309.
[43] SU Nanwei,LIN YiiLih,LEE MinHsiung,et al.Ankaflavin from Monascus-fermented red riceexhibits selective cytotoxic effect and induces cell death on Hep G2 cells [J]. Journal of Agricultural and Food Chemistry,2005,53(6):1 949-1 954.
[44] CHENG Chihfu,PAN Tzuming.Ankaflavin and monascininduce apoptosis in activated hepatic stellate cells through suppression of the Akt/NF-κB/p38 signaling pathway [J].Journal of Agricultural and Food Chemistry,2016,64(49):9 326-9 334.
[45] SHAYMAA W E,MAGED W H,SHERINE N K, et al.Phytosomal bilayer-enveloped casein micelles for codelivery of monascus yellow pigments and resveratrol to breast cancer[J].Nanomedicine,2018,13(5):481-499.
[46] SHAYMAA W E,MAGED W H,SHERINE N K,et al.Folate conjugated vs PEGylatedphytosomal casein nanocarriers for codelivery of fungal- and herbal-derived anticancer drugs[J].Nanomedicine, 2018,13(12): 1 463-1 480.
[47] CHENG Chihfu,PAN Tzuming.Monascus-fermented red mold dioscorea protects mice against alcohol-induced liver injury, whereas its metabolites ankaflavin and monascin regulate ethanol-induced peroxisome proliferator-activated receptor-γ and sterol regulatory element-binding transcrip [J].Journal of the Science of Food and Agriculture,2018,98(5):1 889-1 898.
[48] 陈冠敏,林蔚,林春芳,等.红曲黄色素亚慢性毒性研究[J]. 癌变.畸变.突变,2009(4):316-319.
[49] 中华人民共和国国家卫生和计划生育委员会.GB 1886.181—2016食品安全国家标准食品添加剂红曲红[S].北京:中国标准出版社, 2016.
[50] 张淑娟,江美丽,彭孟春,等.连二亚硫酸钠热分解特性动力学及危险性评价[J].安全与环境学报, 2014(5):39-44.
[51] HUANG Tao,TAN Hailing,LU Fangju,et al.Changing oxidoreduction potential to improve water-soluble yellow pigment production with Monascus ruber CGMCC 10910 [J].Microbial Cell Factories, 2017, 16(1):208.
[52] KLINSUPA W,PHANSIRI S,THONGPRADIS P, et al.Enhancement of yellow pigment production by intraspecific protoplast fusion of Monascus spp. yellow mutant (ade-) and white mutant (prototroph)[J].Journal of Biotechnology,2016,217:62-71.
[53] LV Jun,ZHANG Bobo,LIU Xiaodong,et al.Enhanced production of natural yellow pigments from Monascus purpureus by liquid culture: the relationship between fermentation conditions and mycelial morphology[J].Journal of Bioscience and Bioengineering,2017,124(4):452-458.
[54] LV Jun,QIAN Gaofei,CHEN Lei,et al.Efficient biosynthesis of natural yellow pigments by Monascus purpureus in a novel integrated fermentation system [J].Journal of Agricultural and Food Chemistry,2018,66(4):918-925.
[55] YONGSMITH B,THONGPRADIS P,KLINSUPA W,et al.Fermentation and quality of yellow pigments from golden brown rice solid culture by a selected Monascus mutant [J].Applied Microbiology and Biotechnology,2013,97(20):8 895-8 902.
[56] SHI Kan,TANG Rui,HUANG Tao,et al.Pigment fingerprint profile during extractive fermentation with Monascus anka GIM 3.592 [J]. BMC Biotechnology, 2017,17(1):46.
[57] SHI Kan,SONG Da,CHEN Gong,et al.Controlling composition and color characteristics of Monascus pigments by pH and nitrogen sources in submerged fermentation[J].Journal of Bioscience and Bioengineering,2015,120(2):145-154.
