Ferulic acid has been widely used in food and pharmaceutical industries, but it is easily affected by environmental factors, such as temperature and pH. Solid lipid nanoparticles (SLNs) can effectively protect biologically active substances from degradation. Therefore, ferulic acid loaded SLNs (FA-SLNs) were prepared by thin membrane-ultrasonic method and emulsification-evaporation method. Single-factor experiments were used to select the optimal processing conditions to prepare FA-SLNs by each method. The results showed that FA-SLNs with average particle size of 44.33 nm and potential of -12.35 mV were obtained by thin film-ultrasonic method, with 40 mg ferulic acid (10%, w/w) and lecithin (90%,w/w) added, and the ultrasonic time was 5 min. The encapsulation efficiency was 62.97%. FA-SLNs prepared by emulsification and evaporation method had ferulic acid (4% w/w), lecithin (16% w/w), and monoglyceride (80%, w/w) added, and the concentration of polyether F-68 added was 10 g/L. The average particle size of FA-SLNs prepared under this condition was 141.37 nm, the potential was -10.25 mV, and the encapsulation efficiency was 69.54%. The size of FA-SLNs prepared by thin film-ultrasonic method was smaller, and the encapsulation efficiency of FA-SLNs prepared by emulsification and evaporation method was higher. Moreover, samples prepared under the optimal conditions for both methods could be stored stably for 21 days at 4 ℃ without observing any precipitates.
GAO Yimin
,
ZHANG Zhen
,
CHEN Peimin
,
CHEN Qin
,
ZHOU Yunying
,
WANG Yong
,
ZHANG Ning
. Preparation and comparison of ferulic acid solid lipid nano-particles made by emulsification evaporation and thin film-ultrasonic method[J]. Food and Fermentation Industries, 2019
, 45(6)
: 127
-132
.
DOI: 10.13995/j.cnki.11-1802/ts.017585
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