Food and Fermentation Industries >

2019 , Vol. 45 >Issue 23: 29 - 36

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.021284

Antidiabetic effects of probiotics compounded with chromium-rich yeast alleviate type 2 diabetes symptoms via regulating gut microbiota imbalance

  • ZHOU Xingting ,
  • YU Leilei ,
  • ZHAI Qixiao ,
  • TIAN Fengwei ,
  • ZHAO Jianxin ,
  • ZHANG Hao ,
  • CHEN Wei
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  • (School of Food Science and Technology, Jiangnan University, Wuxi 214122,China)

Received date: 2019-06-05

  Online published: 2020-02-11

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Abstract

This study explored the mechanism of probiotics with chromium-rich yeast on Type 2 diabetes in mice. The disease was induced by high-fat diet and intraperitoneal injection of STZ. The fifty mice were divided into five groups. The results showed that Type 2 diabetes is closely related to the imbalance of gut microbiota. The level of the short-chain fatty acids (SCFAs) and the diversity of intestinal microbiota in these mice were significantly reduced, the abundance of some beneficial bacteria was decreased and the abundance of pathogenic bacteria was increased. After intervention, the gut microbiota imbalance was alleviated in drug-treated group, probiotics-treated group and cocktail-treated (using mixture of probiotics and chromium-rich yeast) group. Compared with the probiotics-treated group, the cocktail group showed more significant protective effects, including increase in the abundance of Lactobacillus and SCFA levels, and decrease in glucose level and abundance of Coprococcus and Rikenellaceae-g. Therefore, mixture of probiotics and chromium-rich yeast had more effective and comprehensive protective effects on type 2 diabetes. This study provided a theoretical basis for microbial mixture treatment method as an intervention treatment for Type 2 diabetes.

Key words： Probiotic; Chromium-rich yeast; Type 2 diabetes; Gut microbiota; Microbiota imbalance

Cite this article

ZHOU Xingting , YU Leilei , ZHAI Qixiao , TIAN Fengwei , ZHAO Jianxin , ZHANG Hao , CHEN Wei . Antidiabetic effects of probiotics compounded with chromium-rich yeast alleviate type 2 diabetes symptoms via regulating gut microbiota imbalance[J]. Food and Fermentation Industries, 2019 , 45(23) : 29 -36 . DOI: 10.13995/j.cnki.11-1802/ts.021284

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