In order to explore the toxicological safety of L-arginine and antioxidant formulations, this paper focused on the toxicological evaluation of L-arginine, hawthorn extract, anemarrhena extract and astaxanthin formulations in accordance with “The Technical Specification for Inspection and Evaluation of Health Food ”(2003 edition). Toxicology studies showed that the maximum tolerance dose to mice of for the formula was more than 20.0 g/(kg·BW). The results of Ames test,mouse bone marrow micronucleus test and mice sperm abnormality test were negative.For the 30 days oral toxicity test, the parameters were in the range of normal value. No significant toxic effects were found for the formula in this study.The formula is non-toxic, non-genotoxic, and does not cause mutations. Provide the scientific basis of toxicology for its clinical application and health food research and development.
ZHAO Yan
,
ZHAO Baolu
. Toxicological and safety research of a formula containing L-argarginine and antioxidants[J]. Food and Fermentation Industries, 2020
, 46(6)
: 108
-113
.
DOI: 10.13995/j.cnki.11-1802/ts.023437
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