An analytical method for the accurate determination of multiple heavy metal elements in aquatic product by inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) was established. For the spectral interferences caused by complex matrices in ICP-MS/MS analysis, O2 was introduced into the octopole reaction system (ORS) as the reaction gas in the MS/MS mode. The analyte Cr+, Ni+, and As+ could react with O2 to form CrO+, NiO+, and AsO+, respectively. While interference ions did not react with O2, the O2 mass shift method was used to eliminate the spectral interferences. Using Sc, In, and Bi as internal standard elements, the matrix effect was corrected and the drift of the analysis signal was prevented. The interference free determination of trace heavy metal elements Cr, Ni, As, Cd, Hg, and Pb in aquatic product was realized. The accuracy of the method proposed was evaluated by analysis of scallop composition analysis certified reference material (GBW10024). The detection limits of analytes ranged from 0.85 to 4.28 ng/L. The relative standard deviation (RSD) was ≤4.65%. Thus, ICP-MS/MS operated in the reaction mode was an effective instrumental strategy for overcoming spectral interferences, which allows the accurate determination of multiple heavy metal elements in aquatic product at trace levels.
LI Aiyang
,
WU Suyun
,
LIU Ning
,
LIU Shuilin
. Determination of trace heavy metal elements in aquatic product by inductivelycoupled plasma tandem mass spectrometry[J]. Food and Fermentation Industries, 2020
, 46(9)
: 260
-264
.
DOI: 10.13995/j.cnki.11-1802/ts.023012
[1] PERELLO G, MARTI-CID R, LLOBET J M, et al. Effects of various cooking processes on the concentrations of arsenic, cadmium, mercury, and lead in foods [J]. Journal of Agricultural and Food Chemistry, 2008, 56(23): 11 262-11 269.
[2] 李倩云, 周国燕, 曹蕾. 微波消解-电感耦合等离子体质谱法检测虾中铅含量[J].食品与发酵工业, 2016, 42(4): 193-196.
[3] 夏松养. 水产品食品加工学[M]. 北京: 化学工业出版社, 2008: 1-7.
[4] FU L, SHI S, CHEN X. Multi-element analysis of water decoction of medicine food homology plants using inductively coupled plasma-tandem mass spectrometry[J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 2017, 133: 34-39.
[5] FU L, SHI S, CHEN X. Accurate quantification of toxic elements in medicine food homologous plants using ICP-MS/MS [J]. Food Chemistry, 2018, 245: 692-697.
[6] GB 2762—2017, 食品安全国家标准食品中污染物限量[S].北京: 中国标准出版社, 2017.
[7] TUZEN M. Determination of heavy metals in fish samples of the middle Black Sea (Turkey) by graphite furnace atomic absorption spectrometry [J]. Food Chemistry, 2003, 80(1): 119-123.
[8] UYSAL K, EMRE Y, KOSE E. The determination of heavy metal accumulation ratios in muscle, skin and gills of some migratory fish species by inductively coupled plasma-optical emission spectrometry (ICP-OES) in Beymelek Lagoon (Antalya/Turkey) [J]. Microchemical Journal, 2008, 90(1): 67-70.
[9] 方玲, 马海霞, 李来好, 等. 华南沿海地区近江牡蛎重金属污染调查与评价[J]. 食品与发酵工业, 2018, 44(5): 237-243.
[10] DJEDJIBEGOVIC J, LARSSEN T, SKRBO A, et al. Contents of cadmium, copper, mercury and lead in fish from the Neretva river (Bosnia and Herzegovina) determined by inductively coupled plasma mass spectrometry (ICP-MS) [J]. Food Chemistry, 2012,131(2): 469-476.
[11] IGLESIAS M, GILON N, POUSSEL E, et al. Evaluation of an ICP-collision/reaction cell-MS system for the sensitive determination of spectrally interfered and non-interfered elements using the same gas conditions [J]. Journal of Analytical Atomic Spectrometry, 2002, 17(10): 1 240-1 247.
[12] YAMADA N. Kinetic energy discrimination in collision/reaction cell ICP-MS: Theoretical review of principles and limitations [J]. Spectrochimica Acta Part B: Atomic Spectroscopy, 2015, 110: 31-44.
[13] VETERE A, PRCFROCK D, SCHRADER W, et al. Quantitative and qualitative analysis of three classes of sulfur compounds in crude oil [J]. Angewandte Chemie International Edition, 2017, 56(36): 10 933-10 937.
[14] NELSON J, HOPFER H, SILVA F, et al. Evaluation of GC-ICP-MS/MS as a new strategy for specific heteroatom detection of phosphorus, sulfur, and chlorine determination in foods[J]. Journal of Agricultural and Food Chemistry, 2015, 63(18): 4 478-4 483.
[15] BOTING K, TREU S, LEONHARD P, et al. First experimental proof of asymmetric charge transfer in ICP-MS/MS (ICP-QQQ-MS) through isotopically enriched oxygen as cell gas [J]. Journal of Analytical Atomic Spectrometry, 2014, 29(3): 578-582.
[16] GONG J, SOLIVIO M J, MERINO E J, et al. Developing ICP-MS/MS for the detection and determination of synthetic DNA-protein crosslink models via phosphorus and sulfur detection [J]. Analytical Bioanalytical Chemistry, 2015, 407: 2 433-2 437.
[17] HU X, CAO Z, SUN W, et al. Accurate determination of arsenic and selenium in plant food samples by using ICP-MS/MS [J]. Analytical Methods, 2016, 8(32): 6 150-6 157.
[18] MEYER S, MATISSEK M, MULLER S M, et al. In vitro toxicological characterisation of three arsenic-containing hydrocarbons [J]. Metallomics, 2014, 6(5): 1 023-1 033.
[19] JACKSON B P. Fast ion chromatography-ICP-QQQ for arsenic speciation [J]. Journal of Analytical Atomic Spectrometry, 2015, 30(6): 1 405-1 407.
[20] KAWAGUCHI H, TANAKA T, NAKAMURA T, et al. Matrix effects in inductively coupled plasma mass spectrometry [J]. Analytical Sciences, 1987, 3(4): 305-308.
[21] BALCAEN L, BOLEA-FERNANDEZ E, RESANO M, et al. Accurate determination of ultra-trace levels of Ti in blood serum using ICP-MS/MS [J]. Analytica Chimica Acta, 2014, 809: 1-8.
