In this study, the effect of ingestion of acetic acid bacterial powder-containing food (AF) on acute alcoholic liver injury was evaluated. ICR mice (male, 20-22 g) were randomly divided into control group, ethanol group, and ethanol + AF group. 12 mL/kg of 50% ethanol was orally administered to the ethanol group. In ethanol + AF groups, three different doses of AF were administered (0.033, 0.067, 0.200 g/kg). Serum marker of liver injury and liver marker of oxidative stress were measured. Lipid accumulation in liver was evaluated by quantifying triglyceride and histopathological analysis. Our results showed that increase of serum alanine aminotransferase level and decrease of liver reduced glutathione were observed by ethanol ingestion comparing with control group. These impairments were ameliorated by AF ingestion at dose of 0.200 g/kg. Elevation of liver TG level and histopathological score were induced by ethanol ingestion and alleviated by AF administration. These results suggested that ingestion of AF might ameliorate acute alcoholic liver injury.
CHEN Xiaoxue, TIAN Simin, CHENG Yongqiang
. Effect of acetic acid bacterial powder-containing food on acute alcoholicliver injury in ICR mice[J]. Food and Fermentation Industries, 0
: 114
-118
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DOI: 10.13995/j.cnki.11-1802/ts.023449
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