This research aimed to evaluate the application of conjugated linoleic acid (CLA) as a functional component in formula food for patients with colitis, and probiotics can play an important role in the colon by producing CLA. Therefore, these ingredients were added to nutritional formulas to explore their effects on mice with chronic ulcerative colitis (UC). 50 specific pathogen free (SPF) C57BL/6J mice (male, 8 weeks, 18-20 g) were randomly divided into control group, experimental group including nutrition formula group B, C(including 1% CLA), P(containing 1×109 CFU/mL probiotics). Mice were administered 20-30 g/L dextran sulfate sodium (DSS) in their drinking water for three cycles to induce chronic colitis except the control group. Then the experimental groups were given sterilized water and fed nutrition formula B, C, P ad libitum for 2 weeks. The body weight, colon length, myeloperoxidase (MPO), pathological sections, inflammatory factors, and microbial composition were used as evaluation indicators to assess the effects of different dietary supplements on the recovery of mice with UC. Results showed that all the dietary supplements were beneficial against UC compared with the DSS-induced mice. Among them, diet with CLA or probiotic had better effect on colon length, cytokine expression body weight, MPO, and gut microbial composition, respectively. Nutrition formula diet in this research was beneficial to UC and the effect of diet with CLA or probiotic were better.
QIAN Cheng
,
WANG Hongchao
,
ZHANG Qiuxiang
,
ZHAO Jianxin
,
ZHANG Hao
,
CHEN Wei
,
LU Wenwei
. Effects of formula food with conjugated linoleic acid on releasing ulcerative colitis[J]. Food and Fermentation Industries, 2020
, 46(17)
: 87
-93
.
DOI: 10.13995/j.cnki.11-1802/ts.023611
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