This study aimed to evaluate the protective effect of Moringa oleifera leaves polyphenol extract (MLE) on ultraviolet (UV)-induced damages to mice skin. The effects of MLE on hydroxyproline (HYP), hyaluronic acid (HA), oxidative stress, matrix metalloproteinases (MMPs), and morphology in the photoaging skin of mice were analyzed. The results showed that MLE could significantly increase the contents of HYP and HA in the photoaging skin (P<0.05). While UV radiation could significantly increase oxidative stress in mice skin, MLE increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and the content of glutathione (GSH) of the photoaging skin (P<0.05 or P<0.01), and also MLE significantly decreased the content of malondialdehyde (MDA) of the photoaging skin (P<0.01), which indicated that MLE could regulate oxidative stress of the photoaging skin. Additionally, UV radiation significantly increased the content of MMPs (MMP-1, MMP-3 and MMP-9) of the photoaging skin (P<0.01), while MLE reduced the content of MMPs (MMP-1, MMP-3 and MMP-9) of the photoaging skin (P<0.05 or P<0.01). Furthermore, MLE could effectively improve the tissue morphology and collagen structure of the photoaging skin. In conclusion, the protective effect of MLE on the photoaging mice skin might be closely related to the anti-oxidative and anti-inflammatory activities of its polyphenols.
SUN Liping
,
LI Pengcheng
,
ZHUANG Yongliang
,
SUN Yun
. Protective effects of Moringa oleifera leaves polyphenol extracts on photoaging mice skin[J]. Food and Fermentation Industries, 2020
, 46(18)
: 67
-71
.
DOI: 10.13995/j.cnki.11-1802/ts.023730
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