A Box-Behnken response surface methodology was adopted to optimize the technical conditions of explosion puffing drying for Agaricus bisporus based on the single factor experiment.The effects of moisture content(X1),thicknesses of sliced(X2),microwave power(X3) of the three factors on expansion ratios(Y1) and sense quality(Y2) of product were analyzed.Based on the experimental data,the quadratic regression models of two indexes were deduced,then,variables were analyzed with response surface methodology(RSM).The optimized technical conditions of explosion puffing for Agaricus bisporus were obtained.The results indicated that the optimal technical conditions were obtained as follows: microwave power of 540W,the thickness of Agaricus bisporus chips was 8mm and the moisture content of 38%.The expansion ratio and sense quality reached maximum of 195% and 9.5,respectively.