The peptides was obtained by submerged fermentation of cod fish skin after which was cracked with Aspergillus oryzae utilized,The optimization was started from 8 aspects-the carbon and nitrogen ratio,liquid volume,substrate concentration,rotation speed,carbon resource,surfactants,different initial pH,inoculation rate,after which the most important factors was chosen-carbon and nitrogen ratio,inoculum,substrate concentration to do the response surface experiment.The optimum fermentation conditions were as follows: 0.29 ratio of carbon and nitrogen,7.0%substrate concentration,inoculum size 4×107,then the ratio of hydrolysis could come up to 36%,the molecular weight below 1000 took up about 71.5% of fementation peptide.This paper also monitored the activity of antioxidation as well as antihypertense of the peptides,which proved that the IC50 of DPPH could be 1.3 mg/mL,The IC50 of anti-ACE of peptides was 0.88 mg/mL,the peptide of this paper was in low molecular weight with high activity of antioxidation and antihypertense.