Several membrane separation techniques,including ceramic membrane,ultrafiltration membrane and nanofiltration membrane,have been studied on mycophenolic acid production.The optimized conditions have been obtained.This method simplifies the mycophenolic acid production process,enhances product purity and yield,and promotes the benefit of environmental safety.The yield is increased to 65%~70%,the input organic solvent is reduced by 70%,and the usage of organic solvent was decreased by 80%,so the production cost was significantly reduced.The method also presents great application value under the current policies which advocate resource conservation,green production,and sustainable development.