To observe the fibrinolytic function of fermentation broth of Lyophyllum ulmarium(L.u) in vitro and its hypolipidemic effect in vivo.Methods: The activity of L.u was measured by clot liquefaction time and the effect of L.u on bleeding time and coagulation time were observed after L.u treatment.The hyperlipidemic animal model was established,and then the effect of L.u on blood lipids was evaluated.Results: L.u prolonged the coagulation time and bleeding time,reduced the serum levels of total triglycerides and total cholesterols in hyperlipidemic animals.Conclusions: L.u has the fibrinolytic function.The effects may be due to its anticoagulant and hypolipidemic function.