Calcium propionate for food additive was prepared by egg shells.Optimal Conditions for preparation were obtained by orthogonal test and single-factor experiment.The main factors of the reaction were examined by orthogonal experiment.They were as follows: reaction temperature> reaction time.Secondary factors were selected as the solid-liquid ratio of 1:10 and the amount of propionic acid 150% of the theoretical value.The best conditions were determined by single-factor test: reaction temperature 60℃,reaction time 6.5h,the yield was 70.35%.The purity of product was 96% by atomic absorption spectrometry.