Phycocyanin,a natural blue dye,has been widely used in food,cosmetics,medicine,and molecular probes due to its physiological properties such as anti-oxidant,radical scavenging,immunology improving,and hepatocyte protection.Without a stable-effective-economic system,the production of phycocyanin in large scale will not be realized.This paper summarizes several powerful technologies developed rapidly in recent years.The purpose is to offer some references for the study of how to produce phycocyanin effectively.