In order to separate and purify flavones from litchi kernels,static adsorption behaviors of litchi kernel flavones on four kinds of macroporous resins were studied and the optimum kind of macroporous resin was screened.The adsorption performance of the proper macroporous resin for litchi kernel flavones was studied and the optimum parameters of adsorption were obtained.The results showed that HPD800 macroporous adsorbent resin was the best kind.The adsorption equilibrium time the resin was 10 h.According to adsorption isotherm experiments,Langmuir isotherm could better describe the adsorption balance process of flavones on HPD800 resin than Freundlich under 25℃.The regression equation was C/Q=C/434.78+1/1.35×434.78(R2=0.999 3),The correlation coefficient was r=0.999 7.The proper pH value of litchi kernel flavones adsorption was 5.0.The best conditions were as follow:flow rate 3.0 mL/min,concentration of litchi kernel flavones 30.81 mg/mL.