The peel of Citrus Reticulatae is the raw material of Pericarpium Citri Reticulatae(PCR),which was easily molded by Penicillium digitatum.The differences of chemical components among Citrus peels(CP),PCR and molded Citrus peels(FCP) were studied by HPLC-DAD-ESI-MSn and GC-MS.In addition,the total flavonoids and polyphenols were also evaluated in different samples.The results showed that the nonvolatile compounds of CP,PCR and FCP peels were similar,but the volatile compounds of these samples varied significantly.The contents of total flavonoids and polyphenols were significantly different among these samples.In molded samples,the pesticides were not able to detect.