The modeling of the transfer of Salmonella enterica serovar Enteritidis( SE) during washing operation of fresh-cut lettuce was investigated. NaClO and multiple antibacterial agents( 250IU / mL nisin + 0. 15% Citric acid + 0. 05% Sodium diacetate,nisin-CA-SD) were chosen as sanitizing agents,and their different abilities in controlling the transfer of SE were compared. The applicability of power function and exponential function of the cleaning environment were also studied. The results showed that the counts of SE transferred from inoculated lettuce to un-inoculated lettuce decreased when washing times increased. Both NaClO and multiple antibacterial agents could not totally inhibit the transfer of SE while washing. However,the use of multiple antibacterial agents helped to reduce cross-contamination of SE. Power function was appropriate to describe and predict the transfer of SE as sanitizing agents for repeated washing.