Peptide-metal chelate is the product of peptide and metal ions by covalent bond. It has the advantages of higher bioavailability,quick absorption and high nutritive value. In addition,peptide-metal chelate has good bioactivities such as antioxidation,antisepsis,immune regulation,hypolipidemic and hypoglycemic effect. Therefore,Peptide-metal chelate has become a hot research topic. In this paper,the synthesis,structure analysis and bioactivity of peptide-metal chelate and its application prospect are reviewed. The purpose is to provide reference to further study and development.