We established an asparagine /glucose( asn /glc) model reaction system and studied inhibitory effect of high and low molecular weight-lysine /glucose Maillard reaction products( H-LGP and L-LGP) on acrylamide formation and its antioxidant activity in the model reaction system. High performance liquid chromatography and radical scavenging rate method were applied. The results showed that H-LGP and L-LGP inhibited acrylamide contents effectively in the asn /glc model system at 150 ℃,with the maximum inhibition rate of 32. 0 % and 31. 4 % at 10 mg /mL,respectively. Moreover,H-LGP and L-LGP at 10 mg /mL could also increase DPPH and ABTS radical scavenging rate in asn /glc model system. In conclusion: lysine /glucose Maillard reaction products could effectively inhibit acrylamide formation and increase antioxidant activity in asn /glc model system.