Coconut(Cocosnucifera L.) endocarp oil extract(CEOE) obtained from the coconut grown up in Hainan island were analyzed on its inhibiting effect on the oxidation of protein carbonyl,hydrogen peroxide scavenging activity,protective effect on hydrogen peroxide-induced oxidative damage to human serum albumin and hydroxyl radical-induced DNA damage.The results showed that CEOE could inhibit the increase of protein carbonyl and hydroperoxides content induced by hydrogen peroxide effectively,and its scavenging activity on hydrogen peroxide was 49.81%at 2.5 mg /mL;meanwhile,CEOE was able to repair the DNA damage induced by hydroxyl radical,which suggested that CEOE might be a new worthy exploiting source of natural antioxidants.