Response surface methodology was used to optimize purification process of ursolic acid from Amygdalus communis L.peel.In order to purify ursolic acid in Amygdalus communis L.peel,adsorption mass and desorption rate were selected as the evaluation indexes,two resins of AB-8 and HPD100 were screened from six resins,and mixed with a certain mass ratio.On the basis of single factor experiments,response surface test was designed by BoxBenhnken experimental principle.The optimum purification process were as follows:sample concentration 0.31 mg/mL,sample pH 5.01,sample flow rate1.0 mL/min;eluent concentration 90%,eluent pH 5.06,eluent flow rate1.0 mL/min.Under the above conditions,ursolic acid purity increased 5.03 times which was from 6.35% to 32%.