[1] BENJAMIN E J,BLAHA M J,CHIUVE S E,et al.Heart disease and stroke statistics—2017 update:a report from the American Heart Association[J].Circulation,2017,135(10):146-603.
[2] 胡盛寿,高润霖,刘力生,等.《中国心血管病报告2018》概要[J].中国循环杂志,2019,34(3):209-220.
[3] SALTER R C,FOKA P,DAVIES T S,et al.The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake[J].Scientific Reports,2016,6:34 368.
[4] WANG C,WANG H,ZHAO Z J,et al.Pediococcus acidilactici AS185 attenuates early atherosclerosis development through inhibition of lipid regulation and inflammation in rats[J].Journal of Functional Foods,2019,60:103 424.
[5] RAMKUMAR S,RAGHUNATH A,RAGHUNATH S.Statin therapy:Review of safety and potential side effects[J].Acta Cardiologica Sinica,2016,32(6):631-639.
[6] MCNEIL J J,RORY W,WOODS R L,et al.Effect of aspirin on cardiovascular events and bleeding in the healthy elderly[J].New England Journal of Medicine,2018,379(16):1 509-1 518.
[7] 刘新.抗菌肽对氧化型低密度脂蛋白(ox-LDL)诱导的小鼠巨噬细胞泡沫化的影响[D].大连:辽宁师范大学,2019.
[8] GUI T,SHIMOKADO A,SUN Y J,et al.Diverse roles of macrophages in atherosclerosis:From inflammatory biology to biomarker discovery[J].Mediators of Inflammation,2012,2012:1-14.
[9] BUCKLEY M L,RAMJI D P.The influence of dysfunctional signaling and lipid homeostasis in mediating the inflammatory responses during atherosclerosis[J].Biochimica Et Biophysica Acta Molecular Basis of Disease,2015,1852(7):1 498-1 510.
[10] MARTINEZ-SANCHEZ S M,GABALDON-HERNANDEZ J A,MONTORO-GARCIA S.Unravelling the molecular mechanisms associated with the role of food-derived bioactive peptides in promoting cardiovascular health[J].Journal of Functional Foods,2020,64:103 645.
[11] 刘东泽.水蛭酶解物对动脉粥样硬化中泡沫细胞的作用及机制研究[D].济南:山东大学,2014.
[12] 霍艳姣.酪蛋白抗氧化肽对LDL氧化和泡沫细胞形成的抑制作用[D].北京:中国农业大学,2016.
[13] JE J Y,QIAN Z J,LEE S H,et al.Purification and antioxidant properties of bigeye tuna (Thunnus obesus) dark muscle peptide on free radical-mediated oxidative systems[J].Journal of Medicinal Food,2008,11(4):629-637.
[14] KIM S Y,JE J Y,KIM S K.Purification and characterization of antioxidant peptide from hoki (Johnius belengerii) frame protein by gastrointestinal digestion[J].Journal of Nutritional Biochemistry,2007,18(1):31-38.
[15] AHN C B,JE J Y,CHO Y S.Antioxidant and anti-inflammatory peptide fraction from salmon byproduct protein hydrolysates by peptic hydrolysis[J].Food Research International,2012,49(1):92-98.
[16] GU L,YE P,LI H,et al.Lunasin attenuates oxidant-induced endothelial injury and inhibits atherosclerotic plaque progression in ApoE-/-mice by up-regulating heme oxygenase-1 via PI3K/Akt/Nrf2/ARE pathway[J].FASEB Journal:Official publication of the Federation of American Societies for Experimental Biology,2019,33(4):836-4 850.
[17] 赵欣.水蛭酶解提取物对血管内皮功能紊乱保护作用的研究[D].济南:山东大学,2014.
[18] LIANG Q F,CHALAMAUAH M,LIAO W,et al.Zein hydrolysate and its peptides exert anti-inflammatory activity on endothelial cells by preventing TNF-α-induced NF-κB activation[J].Journal of Functional Foods,2020,64:103 598.
[19] 王敏.水蛭素抑制血管平滑肌细胞增殖和内皮细胞损伤及其机理的研究[D].济南:山东大学,2004.
[20] 李成龙.发酵酸肉降血脂肽的分离纯化、特性研究及其对血管内皮细胞的影响[D].重庆:西南大学,2016.
[21] CELERMAJER D S,SORENSEN K E,GOOCH V M,et al.Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis[J].Lancet,1992,7,340(8828):1 111-1 115.
[22] WANG Y,ZHAO X,WANG Y S,et al.An extract from medical leech improve the function of endothelial cells in vitro and attenuates atherosclerosis in ApoE null mice by reducing macrophages in the lesions[J].Biochemical and Biophysical Research Communications,2014,455(1-2):119-125.
[23] WEN Z S,XIANG X W,JIN H X,et al.Composition and anti-inflammatory effect of polysaccharides from Sargassum horneri in RAW264.7 macrophages[J].International Journal of Biological Macromolecules,2016,88:403-413.
[24] 刘金萍,李昀,武军驻.动脉粥样硬化细胞研究模型的选择与建立[C].《临床心身疾病》杂志学术研讨会综合刊,2014-12,郑州:《临床心身疾病杂志》编辑部,2014:28.
[25] CHENG M.L,WANG H C,HSU K C,et al.Anti-inflammatory peptides from enzymatic hydrolysates of tuna cooking juice[J].Food and Agricultural Immunology,2015,26(6):1-12.
[26] 陈月华.大米胰酶水解肽在巨噬细胞RAW264.7中的免疫活性研究[D].长沙:长沙理工大学,2016.
[27] KIM Y S,AHN C B,JE J Y.Anti-inflammatory action of high molecular weight mytilus edulis hydrolysates fraction in LPS-induced RAW264.7 macrophage via NF-κB and MAPK pathways[J].Food Chemistry,2016,202:9-14.
[28] MEJIA E G D,DIA V P.Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-κB pathway in the macrophage[J].Peptides,2009,30(12):2 388-2 398.
[29] HIRAI S,HORII S,MATSUZAKI Y,et al.Anti-inflammatory effect of pyroglutamyl-leucine on lipopolysaccharide-stimulated RAW 264.7 macrophages[J].Life Sciences,2014,117(1):1-6.
[30] CANESI F,MATEO V,COUCHIE D,et al.A thioredoxin-mimetic peptide exerts potent anti-inflammatory,anti-oxidant,and atheroprotective effects in ApoE2.Ki mice fed high fat diet[J].Cardiovascular Research,2019,115(2):292-301.
[31] TONG L T,JU Z,WANG L,et al.Peptides derived from rice α-globulin reduce atherosclerosis in apolipoprotein E-deficient mice by inhibiting TNF-α-induced vascular endothelial cells injury[J].Journal of Functional Foods,2019,63:103582.
[32] JONES L D,PANGLOLI P,KRISHNAN H B,et al.BG-4,a novel bioactive peptide from momordica charantia,inhibits lipopolysaccharide-induced inflammation in THP-1 human macrophages[J].Phytomedicine,2018,42:226-232.
[33] LIANG Y,LIN Q L,HUANG P,et al.Rice bioactive peptide binding with TLR4 to overcome H2O2-induced injury in human umbilical vein endothelial cells through NF-κB signaling[J].Journal of Agricultural & Food Chemistry,2018,66(2):440-448.
[34] 李红梅,王显.水蛭素对体外培养的人冠状动脉平滑肌细胞和内皮细胞生长的影响[J].中国循证心血管医学杂志,2015,7(6):792-794;797.
[35] HELDIN C H,WESTERMARK B.Mechanism of action and in vivo role of platelet-derived growth factor[J].Physiological Reviews,1999,79(4):1 283-1 316.
[36] MAGA G,HUBSCHER U.Proliferating cell nuclear antigen (PCNA):A dancer with many partners[J].Journal of Cell Science,2003,116(15):3 051-3 060.
[37] MONTOYA R A,DE MEJIA E G.Pure peptides from amaranth (Amaranthus hypochondriacus) proteins inhibit LOX-1 receptor and cellular markers associated with atherosclerosis development in vitro[J].Food Research International,2015,77:204-214.
[38] TONG L T,JU Z,QIU J,et al.Peptide GEQQQQPGM derived from rice α-globulin reduces the risk of atherosclerosis in hamsters by improving vascular endothelial cells injury[J].RSC Advances,2017,7(78):49 194-49 203.
[39] XU F R,ZHANG J,WANG Z G,et al.Absorption and metabolism of peptide WDHHAPQLR derived from rapeseed protein and inhibition of HUVECs apoptosis under oxidative stress[J].Journal of Agricultural and Food Chemistry,2018,66(20):5 178-5 189.
[40] TANG L H,SAKAI Y,IWAI K,et al.Effect of collagen tripeptide of type I collagen on migration,proliferation and collagen synthesis of human aortic smooth muscle cells[J].Journal of Kanazawa Medical University,2009,34:93-100.
[41] TANG L H,SAKAI Y,UEDA Y,et al.Effects of oral administration of tripeptides derived from type I collagen (collagen tripeptide) on atherosclerosis development in hypercholesterolemic rabbits[J].Journal of Bioscience & Bioengineering,2015,119(5):558-563.
[42] 龚吉军,钟海雁,黄卫文,等.油茶粕多肽降血脂活性研究[J].食品研究与开发,2012,33(10):24-28.
[43] 黄爱良,黄荣志,黄小倩,等.动脉粥样硬化动物模型构建的方法与现状[J].中国组织工程研究,2015,19(27):4 423-4 428.
[44] 马超月. 燕麦多肽的制备及其降血脂和降血压效果研究[D].镇江:江苏大学,2018.
[45] TONG L T,FUJIMOTO Y,SHIMIZU N,et al.Rice α-globulin decreases serum cholesterol concentrations in rats fed a hypercholesterolemic diet and ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice[J].Food Chemistry,2012,132(1):194-200.
[46] 丁进锋,苏秀榕,李妍妍,等.海蜇胶原蛋白肽的降血脂及抗氧化作用的研究[J].天然产物研究与开发,2012,24(3):362-365.
[47] 孙青.大豆肽对大鼠血脂代谢的影响及其抗动脉粥样硬化机理研究[D].济南:山东大学,2013.
[48] 王东红.苦瓜蛋白降脂活性成分纯化及功效评价[D].烟台:烟台大学,2014.
[49] GODGREY S G,CATHERINE A R.Animal models of atherosclerosis[J].Arteriosclerosis Thrombosis & Vascular Biology,2012,32(15):1 104-1 115.
[50] NAKAMURA T,HIROTA T,MIZUSHIMA K,et al.Milk-derived peptides,Val-Pro-Pro and Ile-Pro-Pro,attenuate atherosclerosis development in apolipoprotein E-deficient mice:A preliminary study[J].Journal of Medicinal Food,2013,16(5):396-403.
