A new kind of hollow capsule process,made from pectin-chitosan polymer,carrageenan and starch,was established.The effects of pectin-chitosan polymer ratio and processing conditions on the preparation performance were studied by single factor experiment and response surface experiment.The optimum formulation and process conditions of colon-targeted hollow capsules were obtained by investigating the indicators including capsule size,fragility,water content,drug release and water vapor permeability.The results showed that when the ratio of pectin-chitosan polymer to solid in the gel solution was 40%-50%,the prepared capsules could meet the requirements of colon targeting.The optimum conditions were as follows:the mass fraction of pectin-chitosan polymer to solid in the gel solution was 50%;the volume fraction of glycerol to gel solution was 1%,and drying at 46 ℃.Under these conditions,the water vapor transmission coefficient was( 2.39±0.12) g·mm/(m·d·kPa) for the prepared hollow capsule which with a (10.06±0.83)% water content and a fragility rate of 0.
WU Li
,
FENG Min
,
YOU Linfeng
. Study on the preparation of colon-targeted hollow capsules with pectin-chitosan polymer[J]. Food and Fermentation Industries, 2020
, 46(22)
: 196
-201
.
DOI: 10.13995/j.cnki.11-1802/ts.025095
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