Research progress on the pharmacological action and mechanism of arbutin

  • LIU Xiaoting ,
  • WANG Xinxuan
Expand
  • (School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China)

Received date: 2021-03-07

  Revised date: 2021-04-29

  Online published: 2022-02-28

Abstract

Arbutin is widely used in the cosmetics and pharmaceutical industry due to its whitening and pigment removing properties, and pharmacological effects such as antioxidant, anti-microbial and anti-inflammatory activities. In recent years, it has also been used in improving wine aroma and other food. As people's emphasis on diet and health care, many drugs also develop usage in food. Based on the research results of the pharmacological activities and mechanism of arbutin at home and abroad, this paper summarized the main research progress of the pharmacological activities and mechanisms of arbutin in removing pigment, anti-oxidation, anti-inflammation, bacteriostasis, antitussive, expectorant, antiasthmatic, anti-cancer, radiological protection and cryo-protection, discussed the types of arbutin effect, influence factors, mechanism and effect of the process. On this basis, the research prospect of arbutin was prospected.

Cite this article

LIU Xiaoting , WANG Xinxuan . Research progress on the pharmacological action and mechanism of arbutin[J]. Food and Fermentation Industries, 2022 , 48(2) : 309 -316 . DOI: 10.13995/j.cnki.11-1802/ts.027263

References

[1] 祝上宾, 王英飒, 敬凡尘, 等.熊果苷磷脂复合物的制备、表征及理化性质研究 [J].中草药, 2020, 51(22):5 698-5 704.
ZHU S B, WANG Y S, JING F C, et al.Preparation, characterization and physicochemical properties of arbutin phospholipid complex [J].Chinese Traditional and Herbal Drugs, 2020, 51(22):5 698-5 704.
[2] 刘德文, 马伟, 齐会娟, 等.笃斯越橘、红豆越橘和细叶杜香中β-熊果苷含量的测定 [J].特种经济动植物, 2019, 22(7):24-25.
LIU D W, MA W, QI H J, et al.Determination of β-arbutin content in cranberry, cranberry and dulcet [J].Special Economic Animal and Plant, 2019, 22(7):24-25.
[3] SHANG Y, WEI W P, ZHANG P, et al.Engineering Yarrowia lipolytica for enhanced production of arbutin [J].Journal of Agricultural and Food Chemistry, 2020.
[4] ZHOU H Y, ZHAO J, LI A T, et al.Chemical and biocatalytic routes to arbutin[J].Molecules (Basel, Switzerland), 2019, 24(18):3 303.
[5] SHANG Y, WEI W P, ZHANG P, et al.Engineering Yarrowia lipolytica for enhanced production of arbutin [J].Journal of Agricultural and Food Chemistry, 2020, 68(5):1 364-1 372.
[6] HINCHA D K, OLIVER A E, CROWE J H.Lipid composition determines the effects of arbutin on the stability of membranes [J].Biophysical Journal, 1999, 77(4):2 024-2 034.
[7] 刘彩云, 吴培诚, 梁高卫, 等.3种熊果苷的研究进展 [J].日用化学工业, 2015, 45(9):529-532.
LIU C Y, WU P C, LIANG G W, et al.Research progress of three kinds of arbutin [J].China Detergent & Chemical Industry, 2015, 45(9):529-532.
[8] Arbutin suppresses osteosarcoma progression via miR-338-3p/MTHFD1L and inactivation of the AKT/mTOR pathway [J].FEBS Open Bio, 2021,11(1):289-299.
[9] PARK J J, HWANG S J, KANG Y S, et al.Synthesis of Arbutin–gold nanoparticle complexes and their enhanced performance for whitening [J].Archives of Pharmacal Research, 2019, 42(11):977-989.
[10] EBADOLLAHI S, POURAMIR M, ZABIHI E, et al.The effect of arbutin on expression of tumor suppressor p53, bax/ bcl-2 ratio and oxidative stress induced by tert-butyl hydroperoxide in fibroblast and lncap cell lines [J].Cell Journal, 2020, 22(4):532-541.
[11] LYU L, ZHANG J, TIAN F Q, et al.Arbutin protects HK-2 cells against high glucose-induced apoptosis and autophagy by up-regulating microRNA-27a [J].Artificial Cells, Nanomedicine, and Biotechnology, 2019, 47(1):2 940-2 947.
[12] 杨勇. 美白剂复配对改善皮肤色素沉积的探索 [J].福建轻纺, 2020(7):43-46.
YANG Y.Exploration of whitening agent combination to improve skin pigment deposition [J].The Light & Textile Industries of Fujian, 2020(7):43-46.
[13] 陆彬, 楼鸳鸯, 陈楚楚, 等.熊果苷抑制斑马鱼胚胎黑色素合成的研究 [J].湖南科技大学学报(自然科学版), 2015, 30(1):116-120.
LU B, LOU Y Y, CHEN C C, et al.Inhibition of melanin synthesis in zebrafish embryos by arbutin [J].Journal of Hunan University of Science & Technology(Natural Science Edition), 2015, 30(1):116-120.
[14] 何盾, 吴芳兰, 徐晓芃, 等.熊果苷对黄褐斑鼠模型治疗效果及机制研究 [J].中国现代医学杂志, 2018, 28(34):6-10.
HE D, WU F L, XU X P, et al.Study on therapeutic effect and mechanism of arbutin on chloasma mouse model [J].China Journal of Modern Medicine, 2018, 28(34):6-10.
[15] 唐婕妤, 彭菲.熊果苷的药理作用与资源获取途径研究进展 [J].今日药学, 2015, 2(9):673-677.
TANG J Y, PENG F.Advances in pharmacological effects of arbutin and access to resources [J].Pharmacy Today, 2015, 2(9):673-677.
[16] 郭静, 徐平, 金立元.熊果苷的研究进展 [J].宁夏医学杂志, 2008, 30(3):281-283.
GUO J, XU P, JIN L Y.Research progress of arbutin [J].Ningxia Medical Journal, 2008, 30(3):281-283.
[17] 郑肖莹. 欧洲国家的植物药研究应用近况(待续)——治疗肾、尿道、前列腺疾病的草药 [J].中成药, 1998, 20(7):3-5.
ZHENG X Y.Research and application of herbal medicine in European countries (to be continued)——herbal medicine for the treatment of diseases of kidney, urethra and prostate [J].Chinese Traditional Patent Medicine, 1998, 20(7):3-5.
[18] YE J, GUAN M, LU Y, et al.Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathway [J].Pulmonary Pharmacology & Therapeutics, 2019, 54:53-59.
[19] 王佩, 赖瑛, 吴锡铭.熊果苷抗炎作用的研究 [J].中华中医药学刊, 2008, 26(9):1 933-1 935.
WANG P, LAI Y, WU X M.Study on anti - inflammatory effect of arbutin [J].Chinese Archives of Traditional Chinese Medicine, 2008, 26(9):1 933-1 935.
[20] KAJIWARA R, SETO A, KOFUJITA H, et al.Enhanced antimicrobial activities of polymerized arbutin and its derivatives prepared by oxidative polymerization of arbutin[J].Reactive & Functional Polymers, 2019, 138:39-45.
[21] 张乐, 姜艳艳, 钟昆芮, 等.熊果苷的应用及检测研究进展[C].// 中华中医药学会中药化学分会第九届学术年会论文集(第一册).北京:中华中医药学会, 2014:9.
ZHANG L, JINAG Y Y, ZHONG K R, et al.Progress in the application and detection of arbutin[C].Proceedings of the 9th Annual Conference of Chemistry of Traditional Chinese Medicine Branch of China Association of Traditional Chinese Medicine (Volume 1).Beijing:China Association of Traditional Chinese Medicine, 2014:9.
[22] JANA P, RADOMÍR N, KLÁRA S, et al.Arbutin and decrease of potentially toxic substances generated in human blood neutrophils [J].Interdiplinary Toxicology, 2014, 7(4):195-200.
[23] 张恩户, 于妮娜, 刘敏, 等.女贞叶提取物及其成分熊果苷祛痰、镇咳作用的实验研究 [J].江苏中医药, 2005, 26(11):69-70.
ZHANG E H, YU N N, LIU M, et al.Experimental study on expectorant and antitussive effects of extract from privet leaf and its constituent arbutin [J].Jiangsu Journal of Traditional Chinese Medicine, 2005, 26(11):69-70.
[24] 郑晓珂, 毕跃峰, 冯卫生, 等.卷柏化学成分研究 [J].药学学报, 2004, 39(4):266-268.
ZHENG X K, BI Y F, FENG W S, et al.Study on the chemical constituents of Cyprinus scrolls[J].Acta Pharmaceutica Sinica, 2004, 39(4):266-268.
[25] 王亚芳, 周宇辉, 张建军.熊果苷镇咳、祛痰及平喘的药效学研究 [J].中草药, 2003, 34(8):739-741.
WANG Y F, ZHOU Y H, ZHANG J J, et al.Pharmacodynamics of arbutin in antitussive, expectorant and antiasthmatic effects [J].Chinese Traditional and Herbal Drugs, 2003, 34(8):739-741.
[26] HAJAR S, EBRAHIM Z, MAHDI P, et al.Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL-1β and TNF-α in LNCaP;prostate cancer [J].Journal of Food Biochemistry, 2020, 44(9):e13360.
[27] JIANG L, WANG D, ZHANG Y, et al.Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells [J].International Journal of Molecular Medicine, 2018, 41(2):1 048-1 054.
[28] 郭锦辉, 高卫芳, 邓智建.熊果苷对膀胱癌EJ-1细胞增殖的影响及其机制研究 [J].广州中医药大学学报, 2019, 36(7):1 069-1 073.
GUO J H, GAO W F, DENG Z J.Effect of arbutin on proliferation of bladder cancer EJ-1 cells and its mechanism [J].Journal of Guangzhou University of Traditional Chinese Medicine, 2019, 36(7):1 069-1 073.
[29] WANG C Q, WANG X M, LI B L, et al.Arbutin suppresses osteosarcoma progression via miR-338-3p/MTHFD1L and inactivation of the AKT/mTOR pathway [J].FEBS Open Bio, 2020, 11(1):289-299.
[30] 李佳, 吕雪莲, 秦新新, 等.熊果苷抑制胰腺癌细胞生长及好氧糖酵解的研究 [J].中国临床药理学杂志, 2020, 36(19):3 070-3 074.
LI J, LYU X L, QIN X X, et al.Inhibitory effect of arbutin on growth and aerobic glycolysis of pancreatic cancer cells [J].The Chinese Journal of Clinical Pharmacology, 2020, 36(19):3 070-3 074.
[31] NADI S, MONFARED A S, MOZDARANI H, et al.Effects of arbutin on radiation-induced micronuclei in mice bone marrow cells and its definite dose reduction factor [J].Iranian Journal of Medical Sciences, 2016, 41(3):180-185.
[32] NADI S, ELAHI M, MORADI S, et al.Radioprotective effect of arbutin in megavoltage therapeutic X-irradiated mice using liver enzymes assessment[J].Journal of Biomedical Physics & Engineering, 2019, 9(5):533-540.
[33] ROSA S C, GONÇALVES J, JUDAS F, et al.Assessment of strategies to increase chondrocyte viability in cryopreserved human osteochondral allografts:Evaluation of the glycosylated hydroquinone, arbutin [J].Osteoarthritis and Cartilage, 2009, 17(12):1 657-1 661.
[34] ABOAGLA M E, MAEDA T.Arbutin's suppression of cryodamage in goat sperm and its mechanism of cryoprotection [J].Theriogenology, 2011, 76(3):538-546.
[35] MAN X, YANG L, LIU S, et al.Arbutin promotes MC3T3E1 mouse osteoblast precursor cell proliferation and differentiation via the Wnt/βcatenin signaling pathway [J].Molecular Medicine Reports, 2019, 19(6):4 637-4 644.
[36] LYU L, ZHANG J, TIAN F, et al.Arbutin protects HK-2 cells against high glucose-inducedapoptosis and autophagy by up-regulating microRNA-27a [J].Artificial Cells, 2019, 47(1):2 940-2 947.
[37] SUBRAMANIAN S, LOORDHURANI A, LAKSHMANAN V, et al.Preventive effect of arbutin on isoproterenol-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells [J].International Journal of Nutrition, Pharmacology, Neurological Diseases, 2019, 9(3):97-104.
[38] ZHAO W B, WANG S, QIN T Y, et al.Arbutin attenuates hydrogen peroxide-induced oxidative injury through regulation of microRNA-29a in retinal ganglion cells [J].Biomedicine & Pharmacotherapy, 2019, 112:1-8.
[39] 董钦, 张春晶, 周宏博, 等.熊果苷拮抗H2O2损伤的研究(英文) [J].哈尔滨医科大学学报, 2005, 38(2):142-144.
DONG Q, ZHANG C J, ZHOU H B, et al.Study on the antagonistic effect of arbutin on H2O2 damage[J].Journal of Harbin Medical University, 2005, 38(2):142-144.
[40] ZHOU L, FU X, JIANG L, et al.Arbutin increases Caenorhabditis elegans longevity and stress resistance [J].PeerJ, 2017, 5(12):e4170.
[41] 张永刚, 蒋淑丽, 任志明, 等.熊果苷对小鼠脑缺血再灌注损伤的影响 [J].现代生物医学进展, 2014, 14(8):1 464-1 466.
ZHANG Y G, JIANG S L, REN Z M, et al.Effect of arbutin on cerebral ischemia reperfusion injury in rats [J].Progress in Modern Biomedicine, 2014, 14(8):1 464-1 466.
[42] DASTAN Z, POURAMIR M, GHASEMI K M, et al.Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer's disease [J].The International Journal of Neuroscience, 2019, 129(11):1 145-1 153.
[43] DADGAR M, POURAMIR M, DASTAN Z, et al.Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson's disease [J].Avicenna Journal of Phytomedicine, 2018, 8(6):533-542.
[44] NALBAN N, SANGARAJU R, ALAVALA S, et al.Arbutin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting TLR-4/NF-κB pathway in mice [J].Cardiovascular Toxicology, 2019, 20(6):235-248.
[45] KHADIR F, POURAMIR M, JOORSARAEE S G, et al.The effect of arbutin on lipid peroxidation and antioxidant capacity in the serum of cyclosporine-treated rats [J].Caspian Journal of Internal Medicine, 2015, 6(4):196-200.
[46] TOMMASO C, LUCA G, FRANCESCA M, et al.The efficacy of umbelliferone, arbutin, and N-acetylcysteine to prevent microbial colonization and biofilm development on urinary catheter surface:Results from a preliminary study[J].Journal of Pathogens, 2016:1590952-1590957.
[47] KUZ'NIAK E, WIELANEK M, CHWATKO G, et al.Salicylic acid and cysteine contribute to arbutin-induced alleviation of angular leaf spot disease development in cucumber [J].Journal of Plant Physiology, 2015, 181:9-13.
[48] SKŁODOWSKA M, NALIWAJSKI M, WIELANEK M, et al.Arbutin- and benzotiadiazole-mediated cucumber response to Pseudomonas syringae pv. lachrymans infection in cArbohydrate metabolism [J].Scientia Horticulturae, 2015, 192:200-210.
[49] ANGELO C, ROSA P, MARINA B, et al.Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren) in addition to complex decongestive therapy on management of breast cancer-related lymphedema [J].Supportive Care in Cancer, 2019, 27(4):1 471-1 480.
[50] 沈洋, 吕雪芹, 林璐, 等.蔗糖磷酸化酶的半理性设计及生产α-熊果苷的条件优化 [J].食品与发酵工业, 2020, 46(13):1-9.
SHEN Y, LYU X Q, LIN L, et al.Semi-rational design of sucrose phosphorylase and optimization of production conditions for α-arbutin [J].Food and Fermentation Industries, 2020, 46(13):1-9.
[51] 王晓芊. 熊果苷的潮起潮落——解析美白成分熊果苷 [J].中国化妆品, 2019(10):85-87.
WANG X Q.The ebb and flow of arbutin—analysis of whitening component arbutin [J].China Cosmetics Review, 2019(10):85-87.
[52] 沈洋. 蔗糖磷酸化酶的克隆表达及生物转化制备α-熊果苷的研究 [D].无锡:江南大学, 2020:68.
SHEN Y.Cloning and expression of sucrose phosphorylase and preparation of α-arbutin by biotransformation [D].Wuxi:Jiangnan University, 2020:68.
Outlines

/