Effects of Bifidobacterium breve strains on gut microbiota and metabolites in Aβ-injected mice

  • ZHU Guangsu ,
  • ZHAO Jianxin ,
  • ZHANG Hao ,
  • CHEN Wei ,
  • WANG Gang
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  • (School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

Received date: 2021-06-04

  Revised date: 2021-06-28

  Online published: 2022-03-04

Abstract

To evaluate the effects of Bifidobacterium breve from different sources on intestinal microflora and its metabolites in mice with Alzheimer's diseases (AD) induced by Aβ1-42 injection, an animal model by injecting intrahippocampal Aβ1-42 to mice was established, and two B. breve strains were separately administered to mice for 6 week. The microbial diversity and composition were measured. The microbial diversity and composition were significantly changed after Aβ1-42 injection. Notably, B. breve supplementation displayed various effects on the recovery of gut microbiota dysbiosis. Metagenomic analysis showed that B. breve MY administration dramatically increased the relative abundance of Coprococcus spp., Lactobacillus reuteri and Akkermansia muciniphila at genus and species level. In addition, GC-MS analysis found that supplementation with MY markedly modulated the concentrations of short-chain fatty acids (SCFAs). B. breve MY may delay the progression of AD by modulating the gut microbiota and SCFAs.

Cite this article

ZHU Guangsu , ZHAO Jianxin , ZHANG Hao , CHEN Wei , WANG Gang . Effects of Bifidobacterium breve strains on gut microbiota and metabolites in Aβ-injected mice[J]. Food and Fermentation Industries, 2022 , 48(3) : 70 -77 . DOI: 10.13995/j.cnki.11-1802/ts.028210

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