Fabrication and characterization of lipid coated curcumin/zein nanoparticles

  • LIU Xinyue ,
  • CHEN Xiaoping ,
  • JIAO Lirong ,
  • CHEN Lu ,
  • FENG Fan ,
  • CHEN Li ,
  • XIAO Shengwei ,
  • TIAN Houkuan
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  • (School of Pharmaceutical and Chemical Engineering,Taizhou University,Taizhou 318000,China)

Online published: 2022-04-06

Abstract

Lipid-coated curcumin/zein nanoparticle was fabricated through a two-step method. Nanocore was first synthesized through the co-precipitation of zein and curcumin, then the lipid layer was coated onto the surface through co-extrusion of nanocore and liposome. The resultant nanoparticles showed an average size of 90 nm with high encapsulation efficiency (95.3%) and loading capacity (17.8%). Then the photothermal stability, water dispersion, free radical scavenging capacity and in vitro release behavior were tested. The results showed that, compared with free curcumin and curcumin nanoparticle without lipid layer, water dispersibility, better photo-thermostability and enhanced antioxidation ability were increased in curcumin nanoparticles with lipid coating layer. In addition, the lipid layer at the surface also provided better protection for curcumin across stomach and enables controlled release of curcumin in intestine. Therefore, our core-shell structured nano-delivery system showed great potential on improving the physicochemical properties and oral delivery efficiency of curcumin which could greatly promote the application of curcumin in food and pharmaceutical industries.

Cite this article

LIU Xinyue , CHEN Xiaoping , JIAO Lirong , CHEN Lu , FENG Fan , CHEN Li , XIAO Shengwei , TIAN Houkuan . Fabrication and characterization of lipid coated curcumin/zein nanoparticles[J]. Food and Fermentation Industries, 2022 , 48(5) : 130 -135 . DOI: 10.13995/j.cnki.11-1802/ts.027492

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