Research progress of polyketides

  • PANG Zixuan ,
  • WU Jiheng ,
  • YAN Hao ,
  • WANG Zhiyuan ,
  • LI Ye ,
  • BAI Zhonghu
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  • 1(School of Biotechnology, Jiangnan University, Wuxi 214122, China)
    2(National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, China)

Received date: 2021-05-18

  Revised date: 2021-06-18

  Online published: 2022-04-25

Abstract

Polyketides are a class of secondary metabolites produced by plants or microorganisms and have a wide range of sources in nature. At present, tens of thousands of polyketides have been discovered. Polyketides have been widely used in agriculture, food industry, medical care and other fields based on their complex chemical structures and abundant physiological activities, including antibacterial activity, antitumor activity, antioxidant activity and so on. In recent decades, many studies have been carried out to deeply understanding the mechanism of polyketide biosynthesis. However, natural polyketides cannot fully meet the needs of society, so the construction of unnatural polyketides has become a research hotspot. Therefore, this review mainly summarized the research progress on the classification, structure and catalytic mechanism of polyketide synthase; some natural polyketide compounds and their hosts; the construction technology and application examples of unnatural polyketide compounds, and the biological activities of polyketide compounds. Finally, the shortcomings of current research on polyketide compounds were pointed out, and the development, as well as the application direction of polyketide compounds in the future were prospected.

Cite this article

PANG Zixuan , WU Jiheng , YAN Hao , WANG Zhiyuan , LI Ye , BAI Zhonghu . Research progress of polyketides[J]. Food and Fermentation Industries, 2022 , 48(6) : 316 -326 . DOI: 10.13995/j.cnki.11-1802/ts.028069

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