Mechanism of functional carbohydrates alleviating non-alcoholic fatty liver disease by regulating intestinal flora and metabolites

  • SHANG Weixuan ,
  • LIU Lu ,
  • LEI Suzhen ,
  • ZHANG Yi ,
  • ZENG Hongliang
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  • (College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

Received date: 2021-10-20

  Revised date: 2021-12-21

  Online published: 2022-08-19

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome with abnormal accumulation of fat in hepatocytes and abnormal function of fat metabolism in liver caused by various factors without excessive drinking history. At present, the pathogenesis of NAFLD is not clear, and dietary intervention measures have achieved preliminary results. Therefore, this paper reviews the improvement effect of the functional carbohydrates (including dietary fiber, resistant starch and functional oligosaccharides, etc.) in the diet on NAFLD by promoting the proliferation of beneficial bacteria such as Bifidobacterium and Lactobacillus, inhibiting the growth of Ruminococcus, Enterobacter and other potentially harmful bacteria, regulating the intestinal short chain fatty acids, bile acids, endogenous ethanol and other metabolites, so as to reduce inflammation and oxidative stress, prevent lipid metabolism disorder, and inhibit insulin resistance and obesity.

Cite this article

SHANG Weixuan , LIU Lu , LEI Suzhen , ZHANG Yi , ZENG Hongliang . Mechanism of functional carbohydrates alleviating non-alcoholic fatty liver disease by regulating intestinal flora and metabolites[J]. Food and Fermentation Industries, 2022 , 48(14) : 311 -318 . DOI: 10.13995/j.cnki.11-1802/ts.029741

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