Food and Fermentation Industries >

2022 , Vol. 48 >Issue 22: 292 - 298

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.029816

Determination of perfluoroalkyl sulfonic acid compounds by matrix-assisted laser desorption ionization time of flight mass spectrometry

  • WANG Ning ,
  • LIU Donghao ,
  • RONG Junnan ,
  • ZHOU Qingqiong ,
  • QI Yaqiao ,
  • QI Ping
Expand
  • (Guangzhou Institute for Food Inspection, Guangzhou 511410, China)

Received date: 2021-10-27

  Revised date: 2022-01-24

  Online published: 2022-12-20

Fold

Abstract

A matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) was developed for the rapid detection of perfluoroalkyl sulfonic acid compounds. MALDI-TOF MS signals of five kinds of perfluorobutane sulfonic acid were ana- lyzed using α-cyano-4-hydroxycinnamic acid (HCCA),2,5-dihydroxybenzoic acid (DHB) and sinapinic acid (SA) as a matrix.The spectrum produced by common matrix in negative ion reflection mode and the interference to analytes were investigated. An internal stand- ard quantitative determination method for PFOS was established using HCCA as a matrix,which solved the problem of difficult quantitative determination in MALDI-TOF MS.Results showed that the MALDI-TOF MS internal standard method had good repeatability and sensitivi- ty for the determination of PFOS in water.The linear correlation coefficient R2 was 0.997 9 in the concentration range of 5-500 ng/mL,the recovery rate of water samples was 65% to 106%,and the relative standard deviation (RSD) ranged from 2.36% to 17.7%.This method can be used to detect perfluorooctanesulfonic acid (PFOS) in water,and can effectively realize the rapid quantitative analysis of PFOS in environmental water samples.

Key words： matrix-assisted laser desorption ionization-time of flight mass spectrometry(MALDI-TOF MS); negative reflection mode; perfluoroalkyl sulfonic acid compounds; α-cyano-4-hydroxycinnamic acid; 2,5-dihydroxybenzoic acid; sinapinic acid

Cite this article

WANG Ning , LIU Donghao , RONG Junnan , ZHOU Qingqiong , QI Yaqiao , QI Ping . Determination of perfluoroalkyl sulfonic acid compounds by matrix-assisted laser desorption ionization time of flight mass spectrometry[J]. Food and Fermentation Industries, 2022 , 48(22) : 292 -298 . DOI: 10.13995/j.cnki.11-1802/ts.029816

References

[1] SZNAJDER-KATARZYN' SKA K, SURMA M, CIES' LIK I. A review of perfluoroalkyl acids (PFAAs) in terms of sources, applications, human exposure, dietary intake, toxicity, legal regulation, and methods of determination[J]. Journal of Chemistry, 2019:2717528.
[2] 戚平, 彭名军, 张少仪, 等.食品中全氟烷基酸前处理方法与检测技术研究进展[J]. 现代食品, 2021, 27(12):21-26.
QI P, PENG M J, ZHANG S Y, et al. Research progress on sample pretreatment and analytical methods for determination of PFAAs in foods[J]. Modern Food, 2021, 27(12):21-26.
[3] 贺思思, 史亚利, 蔡亚岐, 等. 全氟/多氟化合物分析方法的研究进展[J]. 色谱, 2020, 38(3):287-296.
HE S S, SHI Y L, CAI Y Q, et al.Research progress on the analytical method of perfluoroalkyl and polyfluoroalkyl substances[J]. Chinese Journal of Chromatography, 2020, 38(3):287-296.
[4] 曹金玲, 席北斗, 许其功, 等. 水环境中PFOA和PFOS的质量浓度分布及其生态毒性[J]. 环境科学, 2011, 32 (10):2 817-2 826.
CAO J L, XI B D, XU Q G, et al. Occurrence of PFOA and PFOS in the aquatic environments and their ecological toxicities in the aquatic environments[J]. Chinese Journal of Environmental Science, 2011, 32(10):2 817-2 826.
[5] 张新, 刘薇, 金一和. 大连沿海常见海产品PFOS和PFOA的暴露水平调查[J]. 环境科学与技术, 2012,35(8):104-106;169.
ZHANG X, LIU W, JIN Y H. Investigation of exposure level of PFOS and PFOA in the body of marine animals in Dalian coastal waters[J]. Environmental Science & Technology, 2012,35(8):104-106;169.
[6] 柳思帆, 王铁宇, 薛科社, 等. 北京水源地鱼体全氟化合物的暴露水平及其健康风险[J]. 生态毒理学报, 2017, 12(1):111 -118.
LIU S F, WANG T Y, XUE K S, et al. Occurrence and human health risk of PFASs in fishes from drinking water sources of Beijing [J]. Asian Journal of Ecotoxicology, 2017, 12(1):111-118.
[7] HAUG L S, SALIHOVIC S, JOGSTEN I E, et al. Levels in food and beverages and daily intake of perfluorinated compounds in Norway[J]. Chemosphere, 2010, 80(10):1 137-1 143.
[8] GAO Y, LI X M, LI X Q, et al. Simultaneous determination of 21 trace perfluoroalkyl substances in fish by isotope dilution ultrahigh performance liquid chromatography tandem mass spectrometry[J]. Journal of Chromatography B, 2018, 1 084:45-52.
[9] BESER M I, PARDO O, BELTRÁN J, et al. Determination of 21 perfluoroalkyl substances and organophosphorus compounds in breast milk by liquid chromatography coupled to orbitrap high-resolution mass spectrometry[J]. Analytica Chimica Acta, 2019, 1 049:123-132.
[10] WANG X Y, SHEN W J, WANG H, et al.Determination of 10 perfluorinated carboxylic acid compounds in water by gas chromatography-mass spectrometry coupled with negative chemical ionization [J]. Chinese Journal of Chromatography, 2019, 37(1):32 -39.
[11] YE Q, CHEN Z B. Analysis of perfluorinated compounds in environmental water using decyl-perfluorinated magnetic mesoporous microspheres as magnetic solid-phase extraction materials and microwave-assisted derivatization followed by gas chromatography-mass spectrometry[J]. Journal of Chromatographic Science, 2018, 56(10):955-961.
[12] SAMIRA H, SERGIO O, MARTINEZ C.Fundamentals of MALDI-TOF-MS Analysis[M]. Singapore:Springer, 2017.
[13] 汪宁, 林子豪, 曾羲, 等. 基质辅助激光解吸电离飞行时间质谱在食品检测中的研究进展[J]. 现代食品, 2020(1):105 -108.
WANG N, LIN Z H, ZENG X, et al. Research progress of matrixassisted laser desorption ionization time-of-flight mass spectrometry on food detection[J]. Modern Food, 2020(1):105-108.
[14] WANG S H, NIU H Y, ZENG T, et al. Rapid determination of small molecule pollutants using metal-organic frameworks as adsorbent and matrix of MALDI-TOF-MS[J]. Microporous and Mesoporous Materials, 2017, 239:390-395.
[15] LI Z J, LIU Q J, LU X H, et al. Magnetic metal-organic framework nanocomposites for enrichment and direct detection of environmental pollutants by negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry[J]. Talanta, 2019, 194:329-335.
[16] LI C Y, GENG H C, ZHU X Q, et al. Self-assembly TiO2 nanosheets as a SALDI-TOF-MS matrix for high-throughput identification of polyfluorinated compounds in water samples[J].Microchemical Journal, 2020, 152:104294.
[17] ZHANG S, LIU J A, CHEN Y,et al.A novel strategy for MALDITOF MS analysis of small molecules[J]. Journal of the American Society for Mass Spectrometry, 2010, 21(1):154-160.
[18] LIN Z A, BIAN W, ZHENG J N, et al. Magnetic metal-organic framework nanocomposites for enrichment and direct detection of small molecules by negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry[J]. Chemical Communications(Cambridge, England), 2015, 51(42):8 785-8 788.
[19] SHROFF R, RULÍSEK L, DOUBSKY J, et al. Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics[J]. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(25):10 092-10 096.
[20] 郝春雁, 刘志强, 宋凤瑞, 等.3种羧酸类基质的基质辅助激光解吸/电离质谱行为[J]. 分析化学,1998,26(2):241-241.
HAO C Y, LIU Z Q, SONG F R, et al. Matrix-assisted laser desorption/ionization mass spectrometry behavior of three carboxylic acid substrates[J]. Chinese Journal of Analytical Chemistry, 1998,26(2):241-241.
[21] CALVANO C D, MONOPOLI A, CATALDI T R I, et al. MALDI matrices for low molecular weight compounds:An endless story?[J].Analytical and Bioanalytical Chemistry, 2018, 410(17):4 015-4 038.
Options
Outlines

/

〈 〉

Powered by Beijing Magtech Co. Ltd,.