Mannitol is an important pharmaceutical, food raw materials and additives. In the traditional industrial production, the crystallization of mannitol is mainly achieved by recrystallization process. The process route is relatively complex, with high energy consumption, difficulty in discharging fusel and low crystallization yield. Simulated moving bed chromatographic separation technology is a continuous chromatographic separation technology that can be produced on a large scale, and can better overcome the above problems. In this study, the separation efficiency of mannitol and the quality of the separated product by triple component simulated moving bed chromatography were studied. Through the research on the selection of chromatographic resin and the optimization of separation parameters, the purity of materials in the crystallization process was improved, and the purpose of shortening the crystallization process, improving the product quality and increasing the mannitol crystallization yield was achieved. The technology in this study was simple and efficient. While the separation process was shortened with low equipment operation cost and high process automation, which opens up a new process route for industrial preparation of high-purity mannitol crystal products.
ZHANG Qianfeng
,
WANG Lizhen
. Separation process of mannitol by simulated moving bed chromatography[J]. Food and Fermentation Industries, 2022
, 48(23)
: 149
-155
.
DOI: 10.13995/j.cnki.11-1802/ts.033157
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