Food and Fermentation Industries >

2024 , Vol. 50 >Issue 5: 54 - 58

DOI: https://doi.org/10.13995/j.cnki.11-1802/ts.027803

Effect of flaxseed oil krill oil soft capsule on blood lipid in hyperlipidemia rats model

  • ZHAI Lei ,
  • CHEN Jianguo ,
  • TIAN Shimin ,
  • ZHANG Pengpeng ,
  • CAI Xiangkun ,
  • ZHENG Lixin
Expand
  • 1(China National Research Institute of Food and Fermentation Industries Co.Ltd., Beijing 100015, China)
    2(CAIQTEST(Beijing) Co.Ltd., Beijing 100123, China)
    3(Chinese Academy of Inspection and Quarantine Comprehensive Test Center, Beijing 100123, China)

Received date: 2021-03-21

  Revised date: 2021-04-15

  Online published: 2024-04-09

Fold

Abstract

In order to investigate the relieving effect of flaxseed oil krill oil soft capsule on hyperlipidemia, 50 male rats were randomly divided into 5 groups.The rats were fed withhigh fat diet for 7 days and orally treated with different doses of flaxseed oil krill oil soft capsule for 30 days.The serum triglyceride(TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in each group were detected to evaluate the efficacy of flaxseed oil krill oil soft capsule in alleviating hyperlipidemia.The results showed as follows,compared with the blank control group, the serum TC, TG and LDL-C contentsin model group were significantly increased (P<0.01), indicating that the model was established; Compared with model blankgroup, TC content of rats in low-dose and high-dose groups was significantly decreased (P<0.05) with reduction of 13.73% and 14.79%, respectively (P<0.05).TG and LDL-C contents of rats in all dose groups were significantly decreased, TG contents were reduced by 45.87%, 55.44% and 64.03%, while LDL-C contents were reduced by 40.54%, 26.12% and 46.85%.Body weight and HDL-C contents of rats in all dose groups were not significantly affected.Therefore, it is concluded that flaxseed oil krill oil soft capsule had assistant hypolipidemic effect.

Key words： flaxseed oil; krill oil; soft capsule; hyperlipidemia

Cite this article

ZHAI Lei , CHEN Jianguo , TIAN Shimin , ZHANG Pengpeng , CAI Xiangkun , ZHENG Lixin . Effect of flaxseed oil krill oil soft capsule on blood lipid in hyperlipidemia rats model[J]. Food and Fermentation Industries, 2024 , 50(5) : 54 -58 . DOI: 10.13995/j.cnki.11-1802/ts.027803

References

[1] 王荣, 杨宽, 罗倩, 等.亚麻籽木酚素对高血脂症大鼠血脂和抗氧化作用研究[J].中国粮油学报, 2020, 35(3):133-138.
WANG R, YANG K, LUO Q, et al.Research on blood lipid and antioxidation of rat with hyperlipidemia from flaxseed lignan[J].Journal of the Chinese Cereals and Oils Association, 2020, 35(3):133-138.
[2] 于美汇, 赵鑫, 尹红力, 等.黑木耳酸性多糖对高血脂症小鼠的降血脂作用[J].食品科学, 2016, 37(15):232-236.
YU M H, ZHAO X, YIN H L, et al.Hypolipemic effect of acidic polysaccharides from Auricularia auricula on hyperlipidemia mice[J].Food Science, 2016, 37(15):232-236.
[3] 王亚恩, 姜国良, 徐恺, 等.南极磷虾油对高脂血症大鼠血脂和抗氧化力的影响[J].中国海洋药物, 2011, 30(3):56-59.
WANG Y E, JIANG G L, XU K, et al.Effects of the Antarctic krill oil on the serum lipids and antioxidation ability in hyperlipidemia rats[J].Chinese Journal of Marine Drugs, 2011, 30(3):56-59.
[4] 王晓菡, 任小娜, 曾俊.亚麻籽油的提取工艺及其生理功能的研究进展[J].粮油加工(电子版), 2014(6):43-46.
WANG X H, REN X N, ZENG J.Research progress of extraction technology and physiological function of flaxseed oil[J].Cereals and Oils Processing (Electronic Version), 2014(6):43-46.
[5] ZHOU D Y, LIU Y X, XU Z L, et al.Effects of long-term intake of Antarctic krill oils on artery blood pressure in spontaneously hypertensive rats[J].Journal of the Science of Food and Agriculture, 2017, 97(4):1143-1148.
[6] SUN D W, ZHANG L, CHEN H J, et al.Effects of Antarctic krill oil on lipid and glucose metabolism in C57BL/6 J mice fed with high fat diet[J].Lipids in Health and Disease, 2017, 16(1):218.
[7] HALS P A, WANG X L, XIAO Y F.Effects of a purified krill oil phospholipid rich in long-chain omega-3 fatty acids on cardiovascular disease risk factors in non-human Primates with naturally occurring diabetes type-2 and dyslipidemia[J].Lipids in Health and Disease, 2017, 16(1):1-16.
[8] SHRAMKO V S, POLONSKAYA Y V, KASHTANOVA E V, et al.The short overview on the relevance of fatty acids for human cardiovascular disorders[J].Biomolecules, 2020, 10(8):1127.
[9] 吴俏槿, 杜冰, 蔡尤林, 等.α-亚麻酸的生理功能及开发研究进展[J].食品工业科技, 2016, 37(10):386-390.
WU Q J, DU B, CAI Y L, et al.Research development of α- linolenic acid[J].Science and Technology of Food Industry, 2016, 37(10):386-390.
[10] 黄莉, 闫实, 孙晓璐, 等.亚麻籽油对小鼠免疫功能的影响[J].中国油脂, 2020, 45(12):56-59;99.
HUANG L, YAN S, SUN X L, et al.Effect of flaxseed oil on immune function of mice[J].China Oils and Fats, 2020, 45(12):56-59;99.
[11] 赵媛媛, 覃骊兰, 郝二伟.高血脂症动物模型研究进展[J].中国实验方剂学杂志, 2018, 24(18):215-221.
ZHAO Y Y, QIN L L, HAO E W.Progress of research on animal model of hyperlipidemia[J].Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(18):215-221.
[12] 彭飞城, 李茂星, 王蓉蓉.大豆磷脂软胶囊辅助降血脂功能研究[J].食品安全质量检测学报, 2018, 9(19):5184-5186.
PENG F C, LI M X, WANG R R.Function of granulesten soft capsule in reducing blood lipid[J].Journal of Food Safety & Quality, 2018, 9(19):5184-5186.
[13] 蒋锐, 姜海斌, 向秋玲, 等.SD大鼠高脂血症模型的建立[J].湖南中医杂志, 2014, 30(5):135-137.
JIANG R, JIANG H B, XIANG Q L, et al.Establishment of Sprague-Dawley rat model of hyperlipidemia[J].Hunan Journal of Traditional Chinese Medicine, 2014, 30(5):135-137.
[14] 赵宝琴, 邹慧, 姜文月, 等.亚麻酸磷脂软胶囊降血脂药理作用[J].安徽农业科学, 2015, 43(23):3-5.
ZHAO B Q, ZOU H, JIANG W Y, et al.Study on pharmacological effect of flax acid phospholipid soft capsules lowering blood lipid[J].Journal of Anhui Agricultural Sciences, 2015, 43(23):3-5.
[15] 陈秀锦, 林蔚, 黄佳宁.磷虾油软胶囊的降脂功能研究[J].预防医学论坛, 2016, 22(7):546-547;550.
CHEN X J, LIN W, HUANG J N.Study on the hypolipidemic activity of superba oil soft capsules[J].Preventive Medicine Tribune, 2016, 22(7):546-547;550.
[16] 祁惠芳, 程子良, 孔维宝, 等.亚麻籽有效成分的提取及其综合利用研究进展[J].中国油脂, 2019, 44(11):102-107.
QI H F, CHENG Z L, KONG W B, et al.Progress in extraction and comprehensive utilization of effective components in flaxseed[J].China Oils and Fats, 2019, 44(11):102-107.
[17] 李先辉, 张洁, 李超, 等.植物α-亚麻酸的生物活性与功效[J].卫生职业教育, 2016, 34(18):144-145;146.
LI X H, ZHANG J, LI C, et al.Biological activity and efficacy of plant α-linolenic acid[J].Health Vocational Education, 2016, 34(18):144-145;146.
[18] 毛艺, 赵鹏飞, 韩君英, 等.两种化学结构的亚麻酸降低血脂的动物实验研究[J].山西医药杂志, 2018, 47(18):2148-2150.
MAO Y, ZHAO P F, HAN J Y, et al.Animal experimental study on reducing blood lipid by linolenic acid with two chemical structures[J].Shanxi Medical Journal, 2018, 47(18):2148-2150.
[19] 王元好, 马岩, 袁起新, 等.南极磷虾油制备技术及其生理功能的研究进展[J].食品研究与开发, 2020, 41(21):220-224.
WANG Y H, MA Y, YUAN Q X, et al.Research progress on extraction and function of Antarctic krill oil[J].Food Research and Development, 2020, 41(21):220-224.
[20] 江利华, 柳慧芳, 郝光飞, 等.虾青素抗氧化能力研究进展[J].食品工业科技, 2019, 40(10):350-354.
JIANG L H, LIU H F, HAO G F, et al.Research progress on antioxidant ability of astaxanthin[J].Science and Technology of Food Industry, 2019, 40(10):350-354.
Options
Outlines

/

〈 〉

Powered by Beijing Magtech Co. Ltd,.