Effects of dietary fiber on depression based on the regulation of intestinal flora

  • BAI Li ,
  • CHENG Xiaoyu ,
  • XU Jiaqian ,
  • YU Jie ,
  • YIN Jizhong ,
  • HUANG Tao ,
  • CUI Shengxuan ,
  • LIU Hui ,
  • XIE Ruining ,
  • QIAO Yi
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  • 1(Weifang Medical University, School of Public Health,Weifang 261053, China)
    2(Jining Medical University, School of Public Health, Jining 272000, China)

Received date: 2023-06-16

  Revised date: 2023-07-03

  Online published: 2024-06-11

Abstract

Due to the increasing pressure of work and life, the prevalence of depression is also rising year by year.As the invisible organ of human body, gut microbiota plays an important role in human life and health, and has become a research hotspot in the field of life science in recent years.With the deepening of research on gut microbiota, there is increasing evidence that gut microbiota can improve depression symptoms through the gut-brain axis.Dietary fiber, as a unique plant polysaccharide, can effectively regulate intestinal flora disturbances.The key role of dietary fiber in coordinating host-microbiome crosstalk has been proven.This paper reviews the evidence of the effects of dietary fiber on intestinal flora and depression, focusing on the mechanism of dietary fiber intervention in intestinal flora to improve depression, in order to provide new ideas and references for the prevention and adjuvant treatment of depression.

Cite this article

BAI Li , CHENG Xiaoyu , XU Jiaqian , YU Jie , YIN Jizhong , HUANG Tao , CUI Shengxuan , LIU Hui , XIE Ruining , QIAO Yi . Effects of dietary fiber on depression based on the regulation of intestinal flora[J]. Food and Fermentation Industries, 2024 , 50(9) : 307 -313 . DOI: 10.13995/j.cnki.11-1802/ts.036489

References

[1] WU S X, LI J H, ZHOU D D, et al.Possible effects and mechanisms of dietary natural products and nutrients on depression and anxiety:A narrative review[J].Antioxidants, 2022, 11(11):2132.
[2] 舒香玲. 低聚木糖改善小鼠抑郁样行为及机制研究[D].无锡:江南大学, 2022.
SHU X L.Xylo-oligosaccharides improves depression-like behavior in mice and its mechanism[D].Wuxi:Jiangnan University, 2022.
[3] JACH M E, SEREFKO A, SZOPA A, et al.The role of probiotics and their metabolites in the treatment of depression[J].Molecules, 2023, 28(7):3213.
[4] SUN Y, CHENG L, ZENG X X, et al.The intervention of unique plant polysaccharides - Dietary fiber on depression from the gut-brain axis[J].International Journal of Biological Macromolecules, 2021, 170:336-342.
[5] SONALI S, RAY B, AHMED TOUSIF H, et al.Mechanistic insights into the link between gut dysbiosis and major depression:An extensive review[J].Cells, 2022, 11(8):1362.
[6] DU Y, GAO X R, PENG L, et al.Crosstalk between the microbiota-gut-brain axis and depression[J].Heliyon, 2020, 6(6):e04097.
[7] 田明, 郑丹, 刘春龙.肠道微生物参与抑郁症发病机制研究进展[J].临床军医杂志, 2022, 50(6):658-660.
TIAN M, ZHENG D, LIU C L.Research progress of intestinal microbes involved in the pathogenesis of depression[J].Clinical Journal of Medical Officers, 2022, 50(6):658-660.
[8] GILL S K, ROSSI M, BAJKA B, et al.Dietary fibre in gastrointestinal health and disease[J].Nature Reviews.Gastroenterology & Hepatology, 2021, 18(2):101-116.
[9] LIANG S, WU X L, HU X, et al.Recognizing depression from the microbiota-gut-brain axis[J].International Journal of Molecular Sciences, 2018, 19(6):1592.
[10] JIANG H Y, LING Z X, ZHANG Y H, et al.Altered fecal microbiota composition in patients with major depressive disorder[J].Brain, Behavior, and Immunity, 2015, 48:186-194.
[11] NIKOLOVA V L, SMITH M R B, HALL L J, et al.Perturbations in gut microbiota composition in psychiatric disorders:A review and meta-analysis[J].JAMA Psychiatry, 2021, 78(12):1343-1354.
[12] LIU L X, WANG H Y, CHEN X Y, et al.Gut microbiota and its metabolites in depression:From pathogenesis to treatment[J].eBioMedicine, 2023, 90:104527.
[13] 饶雪琛. 炎症反应介导的肠道菌群和慢性应激诱导抑郁相关行为的机制研究[D].重庆:重庆医科大学, 2021.
RAO X C.Study on the mechanism of intestinal flora mediated by inflammatory reaction and depression-related behavior induced by chronic stress[D].Chongqing:Chongqing Medical University, 2021.
[14] BUROKAS A, ARBOLEYA S, MOLONEY R D, et al.Targeting the microbiota-gut-brain axis:Prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice[J].Biological Psychiatry, 2017, 82(7):472-487.
[15] GUAN Z W, YU E Z, FENG Q.Soluble dietary fiber, one of the most important nutrients for the gut microbiota[J].Molecules, 2021, 26(22):6802.
[16] MAKKI K, DEEHAN E C, WALTER J, et al.The impact of dietary fiber on gut microbiota in host health and disease[J].Cell Host & Microbe, 2018, 23(6):705-715.
[17] HU R Q, LI S W, DIAO H, et al.The interaction between dietary fiber and gut microbiota, and its effect on pig intestinal health[J].Frontiers in Immunology, 2023, 14:1095740.
[18] SO D, WHELAN K, ROSSI M, et al.Dietary fiber intervention on gut microbiota composition in healthy adults:A systematic review and meta-analysis[J].The American Journal of Clinical Nutrition, 2018, 107(6):965-983.
[19] LIU J, WANG Z W, MAI P S, et al.Quinoa bran soluble dietary fiber ameliorates dextran sodium sulfate induced ulcerative colitis in BALB/c mice by maintaining intestinal barrier function and modulating gut microbiota[J].International Journal of Biological Macromolecules, 2022, 216:75-85.
[20] KIEWIET M B G, ELDERMAN M E, EL AIDY S, et al.Flexibility of gut microbiota in ageing individuals during dietary fiber long-chain inulin intake[J].Molecular Nutrition & Food Research, 2021, 65(4):e2000390.
[21] BENÍTEZ-PÁEZ A, KJØLBÆK L, GÓMEZ DEL PULGAR E M, et al.A multi-omics approach to unraveling the microbiome-mediated effects of Arabinoxylan oligosaccharides in overweight humans[J].mSystems, 2019, 4(4):e00209-e00219.
[22] AMADIEU C, COSTE V, NEYRINCK A M, et al.Restoring an adequate dietary fiber intake by inulin supplementation:A pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients[J].Gut Microbes, 2022, 14(1):2007042.
[23] HIEL S, BINDELS L B, PACHIKIAN B D, et al.Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans[J].The American Journal of Clinical Nutrition, 2019, 109(6):1683-1695.
[24] 付炯兴, 姚伟元, 徐望红.2型糖尿病患者膳食纤维摄入量与肠道菌群的关联:基于一项随机对照试验的数据再分析[J].中华疾病控制杂志, 2022, 26(9):1078-1084.
FU J X, YAO W Y, XU W H.Dietary fiber intake and gut microbiota in Chinese patients with type 2 diabetes:Secondary data analyses of a randomized controlled trial[J].Chinese Journal of Disease Control & Prevention, 2022, 26(9):1078-1084.
[25] LIU Z G, LI L, MA S B, et al.High-dietary fiber intake alleviates antenatal obesity-induced postpartum depression:Roles of gut microbiota and microbial metabolite short-chain fatty acid involved[J].Journal of Agricultural and Food Chemistry, 2020, 68(47):13697-13710.
[26] CHEN L H, LIU B, REN L X, et al.High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients[J].Frontiers in Cellular and Infection Microbiology, 2023, 13:1069954.
[27] SHEN S, PRAME KUMAR K, WEN S W, et al.Deficiency of dietary fiber modulates gut microbiota composition, neutrophil recruitment and worsens experimental colitis[J].Frontiers in Immunology, 2021, 12:619366.
[28] XU H, LI S Y, SONG X X, et al.Exploration of the association between dietary fiber intake and depressive symptoms in adults[J].Nutrition, 2018, 54:48-53.
[29] LIU Y Y, JU Y, CUI L L, et al.Association between dietary fiber intake and incidence of depression and anxiety in patients with essential hypertension[J].Nutrients, 2021, 13(11):4159.
[30] XIA Y, LIU Y S, ZHANG S M, et al.Associations between different types and sources of dietary fibre intake and depressive symptoms in a general population of adults:A cross-sectional study[J].The British Journal of Nutrition, 2021, 125(11):1281-1290.
[31] 徐慧. 成年人膳食纤维摄入与抑郁症的关系研究[D].青岛:青岛大学, 2018.
XU H.Exploration of the association between dietary fiber intake and depressive symptoms in adults[D].Qingdao:Qingdao University, 2018.
[32] 崔伶伶. 膳食纤维摄入对原发性高血压患者抑郁、焦虑影响的横断面调查及随机对照研究[D].苏州:苏州大学, 2021.
CUI L L.The effect of dietary fiber intake on depression and anxiety in patients with essential hypertension:A cross-sectional survey and a randomized controlled study[D].Suzhou:Soochow University, 2021.
[33] KIM C S, BYEON S, SHIN D M.Sources of dietary fiber are differently associated with prevalence of depression[J].Nutrients, 2020, 12(9):2813.
[34] KIM T H, CHOI J Y, LEE H H, et al.Associations between dietary pattern and depression in Korean adolescent girls[J].Journal of pediatric and adolescent gynecology, 2015, 28(6):533-537.
[35] GANGWISCH J E, HALE L, GARCIA L, et al.High glycemic index diet as a risk factor for depression:Analyses from the Women’s Health Initiative1[J].The American Journal of Clinical Nutrition, 2015, 102(2):454-463.
[36] BARBER T M, KABISCH S, PFEIFFER A F H, et al.The health benefits of dietary fibre[J].Nutrients, 2020, 12(10):3209.
[37] MARX W, LANE M, HOCKEY M, et al.Diet and depression:Exploring the biological mechanisms of action[J].Molecular Psychiatry, 2021, 26(1):134-150.
[38] 朱慧越, 邹仁英, 许梦舒, 等.短链脂肪酸-酰化淀粉对小鼠抑郁样行为的缓解及机制[J].食品与发酵工业, 2021, 47(6):26-33.
ZHU H Y, ZOU R Y, XU M S, et al.Short chain fatty acid-acylated starch alleviates depression-like behaviors in mice and its mechanisms[J].Food and Fermentation Industries, 2021, 47(6):26-33.
[39] SWANN O G, KILPATRICK M, BRESLIN M, et al.Dietary fiber and its associations with depression and inflammation[J].Nutrition Reviews, 2020, 78(5):394-411.
[40] PARK H S, KIM J, AHN S H, et al.Epigenetic targeting of histone deacetylases in diagnostics and treatment of depression[J].International Journal of Molecular Sciences, 2021, 22(10):5398.
[41] KUMAR J, RANI K, DATT C.Molecular link between dietary fibre, gut microbiota and health[J].Molecular Biology Reports, 2020, 47(8):6229-6237.
[42] 陈亚婷, 雷梦珠, 张波, 等.慢性应激诱导动物抑郁样行为机制研究进展[J].中国实验动物学报, 2023,31(6):811-819.
CHEN Y T, LEI M Z, ZHANG B, et al.Research progress on mechanisms underlying chronic-stress-induced depressive-liked behavior in animals[J].Acta Laboratorium Animalis Scientia Sinica, 2023,31(6):811-819.
[43] TSAI Y L, LIN T L, CHANG C J, et al.Probiotics, prebiotics and amelioration of diseases[J].Journal of Biomedical Science, 2019, 26(1):3.
[44] CHUDZIK A, ORZYŁOWSKA A, ROLA R, et al.Probiotics, prebiotics and postbiotics on mitigation of depression symptoms:Modulation of the brain-gut-microbiome axis[J].Biomolecules, 2021, 11(7):1000.
[45] MA W J, NGUYEN L H, SONG M Y, et al.Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men[J].Genome Medicine, 2021, 13(1):102.
[46] 郭丽. 菊粉通过肠道菌群调节色氨酸代谢干预精神分裂症小鼠神经炎症的作用及机制研究[D].银川:宁夏医科大学, 2022.
GUO L.Effects and mechanism of inulin on neuroinflammation in Schizophrenia mice by regulating tryptophan metabolism via gut microbiota[D].Yinchuan:Ningxia Medical University, 2022.
[47] GAO K, MU C L, FARZI A, et al.Tryptophan metabolism:A link between the gut microbiota and brain[J].Advances in Nutrition, 2020, 11(3):709-723.
[48] CORREIA A S, VALE N.Tryptophan metabolism in depression:A narrative review with a focus on serotonin and kynurenine pathways[J].International Journal of Molecular Sciences, 2022, 23(15):8493.
[49] DAVIDSON M, RASHIDI N, NURGALI K, et al.The role of tryptophan metabolites in neuropsychiatric disorders[J].International Journal of Molecular Sciences, 2022, 23(17):9968.
[50] PU J C, LIU Y Y, ZHANG H P, et al.An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder[J].Molecular Psychiatry, 2021, 26(8):4265-4276.
[51] XIE T, JIN F, JIA X K, et al.High cellulose diet promotes intestinal motility through regulating intestinal immune homeostasis and serotonin biosynthesis[J].Biological Chemistry, 2021, 403(3):279-292.
[52] KUNDI Z M, LEE J C Y, PIHLAJAMÄKI J, et al.Dietary fiber from oat and rye brans ameliorate western diet-induced body weight gain and hepatic inflammation by the modulation of short-chain fatty acids, bile acids, and tryptophan metabolism[J].Molecular Nutrition & Food Research, 2021, 65(1):e1900580.
[53] LIN C C, HUANG T L.Brain-derived neurotrophic factor and mental disorders[J].Biomedical Journal, 2020, 43(2):134-142.
[54] LI C, CAI Y Y, YAN Z X.Brain-derived neurotrophic factor preserves intestinal mucosal barrier function and alters gut microbiota in mice[J].The Kaohsiung Journal of Medical Sciences, 2018, 34(3):134-141.
[55] AGNIHOTRI N, MOHAJERI M H.Involvement of intestinal microbiota in adult neurogenesis and the expression of brain-derived neurotrophic factor[J].International Journal of Molecular Sciences, 2022, 23(24):15934.
[56] ZHUANG Y, ZENG R Y, LIU X, et al.Neoagaro-oligosaccharides ameliorate chronic restraint stress-induced depression by increasing 5-HT and BDNF in the brain and remodeling the gut microbiota of mice[J].Marine Drugs, 2022, 20(11):725.
[57] CARANDINI T, CERCIGNANI M, GALIMBERTI D, et al.The distinct roles of monoamines in multiple sclerosis:A bridge between the immune and nervous systems?[J].Brain, Behavior, and Immunity, 2021, 94:381-391.
[58] RUHÉ H G, MASON N S, SCHENE A H.Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans:A meta-analysis of monoamine depletion studies[J].Molecular Psychiatry, 2007, 12(4):331-359.
[59] TAO W W, WANG H Q, SU Q, et al.Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice[J].Psychiatry Research, 2016, 238:116-121.
[60] YEHUDA R, SIEVER L J, TEICHER M H, et al.Plasma norepinephrine and 3-methoxy-4-hydroxyphenylglycol concentrations and severity of depression in combat posttraumatic stress disorder and major depressive disorder[J].Biological Psychiatry, 1998, 44(1):56-63.
[61] NOORI T, SUREDA A, SOBARZO-SÁNCHEZ E, et al.The role of natural products in treatment of depressive disorder[J].Current Neuropharmacology, 2022, 20(5):929-949.
[62] D’ALESSANDRO G, LAURO C, QUAGLIO D, et al.Neuro-signals from gut microbiota:Perspectives for brain glioma[J].Cancers, 2021, 13(11):2810.
[63] MITTAL R, DEBS L H, PATEL A P, et al.Neurotransmitters:The critical modulators regulating gut-brain axis[J].Journal of Cellular Physiology, 2017, 232(9):2359-2372.
[64] WU M, TIAN T, MAO Q, et al.Associations between disordered gut microbiota and changes of neurotransmitters and short-chain fatty acids in depressed mice[J].Translational Psychiatry, 2020, 10(1):350.
[65] KRISHNA G, DIVYASHRI G, PRAPULLA S G, et al.A combination supplement of fructo- and xylo-oligosaccharides significantly abrogates oxidative impairments and neurotoxicity in maternal/fetal milieu following gestational exposure to acrylamide in rat[J].Neurochemical Research, 2015, 40(9):1904-1918.
[66] EL MANSARI M, GUIARD B P, CHERNOLOZ O, et al.Relevance of norepinephrine-dopamine interactions in the treatment of major depressive disorder[J].CNS Neuroscience & Therapeutics, 2010, 16(3):e1-e17.
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