Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disease in the world and has become a global epidemic health problem.A legume-based diet can help prevent and control the onset and development of T2DM.To study the health effects of rich γ-aminobutyric acid (GABA) adzuki beans, this study, through the establishment of the T2DM model, analyzed the level of glucose and lipid metabolism and related indexes of liver function in mice with GABA-rich adzuki beans.Results showed that the high dose of GABA-rich adzuki beans (TF3) had a certain effect on the resistance to overweight, and could significantly reduce the level of fasting blood glucose (P<0.05), restore the body′s ability to regulate blood glucose, and alleviate insulin resistance.Compared with the M group, the levels of total cholesterol, triglyceride, alanine transaminase, aspartate transaminase, urea, and creatinine in the serum of T2DM mice were reduced to different degrees in each treatment group, and TF3 and the positive control group had better effects on balancing blood glucose and regulating liver and kidney injury of T2DM mice and could alleviate the pathological injury of liver, pancreas and cecum tissue caused by high-fat diet.Results indicated that a diet rich in GABA adzuki beans could improve the level of small glucose and lipid metabolism, and alleviate the pathological injury of liver, pancreas and cecum tissue, providing a theoretical basis for the development and application of GABA-rich functional foods.
JIANG Xiujie
,
XU Qingpeng
,
ZHANG Jiayu
,
LI Ying
,
WANG Jie
,
CHI Xiaoxing
,
CAO Dongmei
,
ZHANG Dongjie
. Effect of adzuki bean of rich γ-aminobutyric acid on role of glucose and lipid metabolism-regulating in type 2 diabetes mellitus mice[J]. Food and Fermentation Industries, 2024
, 50(12)
: 151
-158
.
DOI: 10.13995/j.cnki.11-1802/ts.038422
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