[1] 王萌, 张毅, 李金田. 从《神农本草经》论茯苓在经方中的应用[J]. 中国中医基础医学杂志, 2017, 23(8):1149-1151.
WANG M, ZHANG Y, LI J T. Application rules of Poria in classical prescriptions analyzed based on Shennong Bencao Jing[J]. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 2017, 23(8):1149-1151.
[2] 李慧敏, 贺凯, 郑慧, 等. 中医药健脾的保健作用机制及药食资源[J]. 中草药, 2020, 51(3):780-787.
LI H M, HE K, ZHENG H, et al. Health-care mechanism and medicine and food resources of invigorating spleen in traditional Chinese medicine[J]. Chinese Traditional and Herbal Drugs, 2020, 51(3):780-787.
[3] 黄一农. 《红楼梦》中最珍贵的药方“暖香丸” 新探[J]. 中国科技史杂志, 2018, 39(1):1-10; 130.
HUANG Y N. The origins of the prized “Warm-fragrance Pill” (Nuanxiang Wan)in dream of the red chamber[J]. The Chinese Journal for the History of Science and Technology, 2018, 39(1):1-10; 130.
[4] 刘玉芳, 阳国彬. 《金匮要略》当归芍药散辨治疑难病验案举隅[J]. 山东中医杂志, 2023, 42(8):874-878.
LIU Y F, YANG G B. Case study on the differentiation and treatment for relapsed and refractory disease with Danggui Shaoyao Powder (当归芍药散) from synopsis of golden chamber [J]. Shandong Journal of Traditional Chinese Medicine, 2023, 42(8):874-878.
[5] HU J R, JUNG C J, KU S M, et al. Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice[J]. Pharmaceutical Biology, 2021, 59(1):321-334.
[6] 国家药典委员会. 中华人民共和国药典-四部: 2020年版[M]. 北京: 中国医药科技出版社, 2020.
Chinese Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China, Volume IV: 2020 Edition[M]. Beijing: China Medical Science and Technology Press, 2020.
[7] WASSER S P. Current findings, future trends, and unsolved problems in studies of medicinal mushrooms[J]. Applied Microbiology and Biotechnology, 2011, 89(5):1323-1332.
[8] 孙宜孔. 汉至唐对茯苓的认识与使用[J]. 西安文理学院学报(社会科学版), 2017, 20(1):60-64.
SUN Y K. The understanding and using of Poria cocos from Han dynasty to Tang dynasty[J]. Journal of Xi’an University (Social Sciences Edition), 2017, 20(1):60-64.
[9] 徐雷, 刘常丽, 郭兰萍. 不同种植模式下茯苓土壤细菌多样性和功能预测分析[J]. 北方园艺, 2023(11):91-97.
XU L, LIU C L, GUO L P. Soil bacterial diversity and function prediction analysis of Poria cocos cultivating under different planting modes[J]. Northern Horticulture, 2023(11):91-97.
[10] ZHAO Y Y, FENG Y L, DU X, et al. Diuretic activity of the ethanol and aqueous extracts of the surface layer of Poria cocos in rat[J]. Journal of Ethnopharmacology, 2012, 144(3):775-778.
[11] 陈卫东, 彭慧, 王妍妍, 等. 茯苓药材的历史沿革与变迁[J]. 中草药, 2017, 48(23):5032-5038.
CHEN W D, PENG H, WANG Y Y, et al. Historical evolution and changes of Poria cocos[J]. Chinese Traditional and Herbal Drugs, 2017, 48(23):5032-5038.
[12] WANG D D, HUANG C G, ZHAO Y, et al. Comparative studies on polysaccharides, triterpenoids, and essential oil from fermented mycelia and cultivated Sclerotium of a medicinal and edible mushroom, Poria cocos[J]. Molecules, 2020, 25(6):1269.
[13] JIN J, ZHOU R R, XIE J, et al. Insights into triterpene acids in fermented mycelia of edible fungus Poria cocos by a comparative study[J]. Molecules, 2019, 24(7):1331.
[14] JIN Y, ZHANG L N, CHEN L, et al. Effect of culture media on the chemical and physical characteristics of polysaccharides isolated from Poria cocos mycelia[J]. Carbohydrate Research, 2003, 338(14):1507-1515.
[15] HAMZA ARMGHAN NOUSHAHI. 茯苓液体发酵条件优化及茯苓酸生物合成和菌丝生长相关基因表达研究[D]. 武汉: 华中农业大学, 2021.
HAMZA A. Optimization of liquid fermentation conditions of Poria cocos and study on biosynthesis of Poria acid and expression of genes related to mycelium growth[D].Wuhan: Huazhong Agricultural University, 2021.
[16] 张诗泉, 郭毓菲, 汪芷玥, 等. 茯苓液体发酵培养条件优化[J]. 食品工业, 2020, 41(4):135-138.
ZHANG S Q, GUO Y F, WANG Z Y, et al. Optimization of fermentation conditions for Poria cocos[J]. The Food Industry, 2020, 41(4):135-138.
[17] 张佩, 陈默, 胡国元. 胞内羧甲基茯苓多糖的发酵动力学[J]. 食品与发酵工业, 2020, 46(6):49-53.
ZHANG P, CHEN M, HU G Y. Study on fermentation kinetics of intracellular carboxymethylpachyman[J]. Food and Fermentation Industries, 2020, 46(6):49-53.
[18] 魏茹丹. 光温与植物油对茯苓液体发酵优化的研究[D]. 武汉: 华中农业大学, 2019.
WEI R D. Optimization of Temperature, Illumination and adding vegetable oil on Poria cocos liquid culture[D]. Wuhan: Huazhong Agricultural University, 2019.
[19] 周燕丽, 卢恒谦, 徐立伟, 等. 液态发酵茯苓菌丝体形态与产胞内三萜的关系[J]. 食品与生物技术学报, 2017, 36(6):635-641.
ZHOU Y L, LU H Q, XU L W, et al. Relationship between Mycelium morphology and intracellular triterpenoids production of Poria cocos in submerged culture[J]. Journal of Food Science and Biotechnology, 2017, 36(6):635-641.
[20] 陈林, 崔培梧, 鲁耀邦, 等. 茉莉酸甲酯对茯苓三萜生物合成的调控研究[J]. 湖南中医药大学学报, 2017, 37(6):606-610.
CHEN L, CUI P W, LU Y B, et al. Study on regulation of triterpenoids biosynthesis in Wolfiporia cocos submerged fermentation system by methyl jasmonate[J]. Journal of Hunan University of Chinese Medicine, 2017, 37(6):606-610.
[21] 廖彦. 茯苓多糖的液态发酵及抗氧化研究[D]. 长沙: 湖南中医药大学, 2017.
LIAO Y. Study on liquid fermentation and antioxidation of Poria cocos polysaccharide[D]. Changsha: Hunan University of Chinese Medicine, 2017.
[22] 邹成梅, 王甜甜, 何思艳, 等. 响应面法优化茯苓多糖发酵培养基[J]. 中国酿造, 2018, 37(7):107-111.
ZOU C M, WANG T T, HE S Y, et al. Optimization of fermentation medium of polysaccharides from Poria cocos by response surface methodology[J]. China Brewing, 2018, 37(7):107-111.
[23] 高学玲, 杨素云, 严云梅, 等. 响应面法优化茯苓菌丝体总三萜的液态发酵工艺[J]. 食品与生物技术学报, 2012, 31(10):1112-1119.
GAO X L, YANG S Y, YAN Y M, et al. Optimical liquid fermentation conditions of total triterpenoids from Poria cocos mycelium by response surface methodology[J]. Journal of Food Science and Biotechnology, 2012, 31(10):1112-1119.
[24] TIAN H, LIU Z J, PU Y W, et al. Immunomodulatory effects exerted by Poria cocos polysaccharides via TLR4/TRAF6/NF-κB signaling in vitro and in vivo[J]. Biomedicine & Pharmacotherapy, 2019, 112:108709.
[25] DONG X X, LI B Y, YU B Y, et al. Poria cocos polysaccharide induced Th1-type immune responses to ovalbumin in mice[J]. PLoS One, 2021, 16(1): e0245207.
[26] HU X R, HONG B Z, SHAN X X, et al. The effect of Poria cocos polysaccharide PCP-1C on M1 macrophage polarization via the Notch signaling pathway[J]. Molecules, 2023, 28(5):2140.
[27] LI Y R, LIU S T, GAN Q, et al. Four polysaccharides isolated from Poria cocos mycelium and fermentation broth supernatant possess different activities on regulating immune response[J]. International Journal of Biological Macromolecules, 2023, 226:935-945.
[28] QIN L, HUANG D N, HUANG J, et al. Integrated analysis and finding reveal anti-liver cancer targets and mechanisms of pachyman (Poria cocos polysaccharides)[J]. Frontiers in Pharmacology, 2021, 12:742349.
[29] 汤建平, 杨吉成, 盛伟华, 等. 羧甲基茯苓多糖对人外周血淋巴细胞分泌IFN-α和IFN-γ的调节作用及中间体制备[J]. 中国生化药物杂志, 1998, 18(2):69-73.
TANG J P, YANG J C, SHENG W H, et al. Modelation of CMP on HPBL secretion of IFN-α and IFN-γ and preparation of their intermediates[J]. Chinese Journal of Biochemical Pharmaceutics, 1998, 18(2):69-73.
[30] KANAYAMA H, ADACHI N, TOGAMI M. A new antitumor polysaccharide from the mycelia of Poria cocos wolf[J]. Chemical & Pharmaceutical Bulletin, 1983, 31(3):1115-1118.
[31] JIANG H Y, DUANMU Z. Inhibitory effect of Poria cocos polysaccharides on proliferation, migration, and invasion of lung cancer cells, A549[J]. Current Topics in Nutraceutical Research, 2022, 20(1):147-152.
[32] CHU B F, LIN H C, HUANG X W, et al. An ethanol extract of Poria cocos inhibits the proliferation of non-small cell lung cancer A549 cells via the mitochondria-mediated caspase activation pathway[J]. Journal of Functional Foods, 2016, 23:614-627.
[33] ZHANG M, CHIU L C M, CHEUNG P C K, et al. Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: Cell-cycle arrest and apoptosis induction[J]. Oncology Reports, 2006, 15(3):637-643.
[34] YANG J N, DONG X X, LI B Y, et al. Poria cocos polysaccharide-functionalized graphene oxide nanosheet induces efficient cancer immunotherapy in mice[J]. Frontiers in Bioengineering and Biotechnology, 2023, 10:1050077.
[35] YIN L, HUANG G X, KHAN I, et al. Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ mice[J]. Chinese Medicine, 2022, 17(1):116.
[36] WANG C H, YANG S X, GAO L, et al. Carboxymethyl pachyman (CMP) reduces intestinal mucositis and regulates the intestinal microflora in 5-fluorouracil-treated CT26 tumour-bearing mice[J]. Food & Function, 2018, 9(5):2695-2704.
[37] LIU X F, WANG X Q, XU X F, et al. Purification, antitumor and anti-inflammation activities of an alkali-soluble and carboxymethyl polysaccharide CMP33 from Poria cocos[J]. International Journal of Biological Macromolecules, 2019, 127:39-47.
[38] CHEN Y Y, CHANG H M. Antiproliferative and differentiating effects of polysaccharide fraction from fu-Ling (Poria cocos) on human leukemic U937 and HL-60 cells[J]. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 2004, 42(5):759-769.
[39] CHEN X Y, ZHANG L N, CHEUNG P C K. Immunopotentiation and anti-tumor activity of carboxymethylated-sulfated β-(1→3)-D-glucan from Poria cocos[J]. International Immunopharmacology, 2010, 10(4):398-405.
[40] HUANG Q L, ZHANG L N, CHEUNG P C K, et al. Evaluation of sulfated α-glucans from Poria cocos mycelia as potential antitumor agent[J]. Carbohydrate Polymers, 2006, 64(2):337-344.
[41] HUANG Q L, JIN Y, ZHANG L N, et al. Structure, molecular size and antitumor activities of polysaccharides from Poria cocos mycelia produced in fermenter[J]. Carbohydrate Polymers, 2007, 70(3):324-333.
[42] JIN Y, ZHANG L N, ZHANG M, et al. Antitumor activities of heteropolysaccharides of Poria cocos mycelia from different strains and culture media[J]. Carbohydrate Research, 2003, 338(14):1517-1521.
[43] BIAN C, XIE N N, CHEN F S. Preparation of bioactive water-soluble pachyman hydrolyzed from sclerotial polysaccharides of Poria cocos by hydrolase[J]. Polymer Journal, 2010, 42(3):256-260.
[44] 林丽霞, 薛银萍, 陈燕, 等. 茯苓多糖对人胃癌裸鼠移植瘤的抑制效应研究[J]. 解放军医药杂志, 2015, 27(11):60-63.
LIN L X, XUE Y P, CHEN Y, et al. Inhibitory effect of pachyman on human gastric cancer of xenografts in nude mice[J]. Medical & Pharmaceutical Journal of Chinese PLA, 2015, 27(11):60-63.
[45] 李琳琳. 茯苓多糖联合顺铂对Lewis肺腺癌移植瘤的抑瘤作用及VEGF、p-STAT3、CD31表达的影响[D]. 张家口: 河北北方学院, 2021.
LI L L. Inhibitory effect of Poria polysaccharide combined with cisplatin on transplanted Lewis lung adenocarcinoma and the expression of VEGF, p-STAT3 and CD31[D]. Zhangjiakou: Hebei North University, 2021.
[46] 闫霜, 王雅莉. 茯苓多糖影响卵巢癌细胞耐药性的机制[J]. 西北药学杂志, 2022, 37(3):94-100.
YAN S, WANG Y L. Study on the effect and mechanism of Poria cocos polysaccharides on drug resistance in ovarian cancer cells[J]. Northwest Pharmaceutical Journal, 2022, 37(3):94-100.
[47] 唐恩红, 蔡旺. 茯苓多糖对人宫颈癌HeLa细胞增殖、迁移、促凋亡的影响及其机制[J]. 肿瘤防治研究, 2019, 46(8):707-713.
TANG E H, CAI W. Effects of pachymaran on proliferation, migration and pro-apoptosis of human cervical carcinoma HeLa cells and its mechanism[J]. Cancer Research on Prevention and Treatment, 2019, 46(8):707-713.
[48] CHOI Y H. Induction of apoptosis by an ethanol extract of Poria cocos Wolf. in human leukemia U937 cells[J]. Oncology Reports, 2015, 34(5):2533-2540.
[49] CHENG S J, ELIAZ I, LIN J F, et al. Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7[J]. International Journal of Oncology, 2013, 42(6):1869-1874.
[50] ZHANG Y H, ZHANG Y, LI X Y, et al. Antitumor activity of the pachymic acid in nasopharyngeal carcinoma cells[J]. Ultrastructural Pathology, 2017, 41(3):245-251.
[51] GAPTER L, WANG Z S, GLINSKI J, et al. Induction of apoptosis in prostate cancer cells by pachymic acid from Poria cocos[J]. Biochemical and Biophysical Research Communications, 2005, 332(4):1153-1161.
[52] SUN K X, XIA H W. Pachymic acid inhibits growth and induces cell cycle arrest and apoptosis in gastric cancer SGC-7901 cells[J]. Oncology Letters, 2018, 16(2):2517-2524.
[53] WANG H B, LUO Y Y, CHU Z W, et al. Poria acid, triterpenoids extracted from Poria cocos, inhibits the invasion and metastasis of gastric cancer cells[J]. Molecules, 2022, 27(11):3629.
[54] CHEN T, HUA L, CHOU G X, et al. A unique naphthone derivative and a rare 4, 5-seco-lanostane triterpenoid from Poria cocos[J]. Molecules, 2018, 23(10):2508.
[55] AKIHISA T, NAKAMURA Y, TOKUDA H, et al. Triterpene acids from Poria cocos and their anti-tumor-promoting effects[J]. Journal of Natural Products, 2007, 70(6):948-953.
[56] AKIHISA T, UCHIYAMA E, KIKUCHI T, et al. Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos[J]. Journal of Natural Products, 2009, 72(10):1786-1792.
[57] LING H, ZHANG Y C, NG K Y, et al. Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression[J]. Breast Cancer Research and Treatment, 2011, 126(3):609-620.
[58] JIANG Y, FAN L P. Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: in vivo and in vitro, identification and mechanism[J]. Journal of Ethnopharmacology, 2020, 257:112851.
[59] LEE S, LEE S, ROH H S, et al. Cytotoxic constituents from the Sclerotia of Poria cocos against human lung adenocarcinoma cells by inducing mitochondrial apoptosis[J]. Cells, 2018, 7(9):116.
[60] 李锐, 谭晓冬, 胡耀元. 茯苓酸对人胰腺癌PANC-1细胞迁移、侵袭和上皮间质转化的抑制作用[J]. 吉林大学学报(医学版), 2023, 49(2):315-323.
LI R, TAN X D, HU Y Y. Inhibitory effect of pachylic acid on migration, invasion, and epithelial-mesenchymal transition of human pancreatic cancer PANC-1 cells[J]. Journal of Jilin University (Medicine Edition), 2023, 49(2):315-323.
[61] 刘洁, 胡晶, 戴娜, 等. 益气解毒方主要三萜类化合物抑制鼻咽癌CNE2细胞增殖效应的比较[J]. 湖南中医药大学学报, 2019, 39(11):1315-1320.
LIU J, HU J, DAI N, et al. Comparison of inhibitory effects of main triterpenoids of Yiqi Jiedu formula on proliferation of nasopharyngeal carcinoma CNE2 cells[J]. Journal of Hunan University of Chinese Medicine, 2019, 39(11):1315-1320.
[62] MA J, LIU J, LU C W, et al. Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells[J]. Cancer Cell International, 2015, 15:78.
[63] CHENG S J, SWANSON K, ELIAZ I, et al. Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress[J]. PLoS One, 2015, 10(4): e0122270.
[64] JEONG J W, LEE W S, GO S I, et al. Pachymic acid induces apoptosis of EJ bladder cancer cells by DR5 up-regulation, ROS generation, modulation of bcl-2 and IAP family members[J]. Phytotherapy Research: PTR, 2015, 29(10):1516-1524.
[65] WEN H L, WU Z, HU H D, et al. The anti-tumor effect of pachymic acid on osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent apoptosis[J]. Journal of Natural Medicines, 2018, 72(1):57-63.
[66] 董建设, 赵俊峰, 张林超, 等. 茯苓酸通过Wnt信号通路对肾癌细胞生物学特性的影响[J]. 中国老年学杂志, 2019, 39(9):2241-2244.
DONG J S, ZHAO J F, ZHANG L C, et al. Effect of pachymic acid on biological characteristics of renal cell carcinoma through Wnt signaling pathway[J]. Chinese Journal of Gerontology, 2019, 39(9):2241-2244.
[67] LAI K H, LU M C, DU Y C, et al. Cytotoxic lanostanoids from Poria cocos[J]. Journal of Natural Products, 2016, 79(11):2805-2813.
[68] 罗园园, 冯心怡, 褚泽文, 等. 茯苓酸通过Smads调控MMP/TIMP平衡抑制肾癌细胞侵袭转移的机制[J]. 中国实验方剂学杂志, 2023, 29(7):76-83.
LUO Y Y, FENG X Y, CHU Z W, et al. Mechanism of pachymic acid in inhibiting invasion and metastasis of renal carcinoma cells via regulating MMP/TIMP balance by smads[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(7):76-83.
[69] 代君怡, 朱瑶, 尹灿, 等. 茯苓有效部位对H22腹水瘤小鼠肿瘤抑制作用的研究[J]. 时珍国医国药, 2022, 33(6):1288-1291.
DAI J Y, ZHU Y, YIN C, et al. Study on tumor inhibition effect of effective part of Poria cocos on mice with H22 ascites tumor[J]. Lishizhen Medicine and Materia Medica Research, 2022, 33(6):1288-1291.