Research progress of liquid fermentation and anti-tumor mechanisms of active substances from Poria cocos

  • TAN Qianwen ,
  • ZOU Cunchao ,
  • HOU Chunying ,
  • LIU Bing ,
  • ZHANG Mingchen ,
  • WANG Zhaosong
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  • 1(Shandong Anran Nano Industrial Development Co.Ltd., Weihai 264205, China)
    2(Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China)

Received date: 2023-09-09

  Revised date: 2023-10-12

  Online published: 2024-08-02

Abstract

The preparation and anti-tumor effects of fermented active substances from Poria cocos are reviewed by searching and classifying the literature from CNKI, PubMed, and Web of Science databases.The review summarizes the effects of different culture media and fermentation conditions on the yield of polysaccharides and triterpenes from Poria cocos, as well as the mechanisms and principles of their action on tumor cells.Results show that:Poria cocos is a kind of natural medicine with wide anti-tumor activity and potential, which can affect the growth, survival, migration, invasion, metastasis, and other aspects of tumor cells through various pathways and mechanisms, thus achieving the purpose of inhibiting tumors.The review points out that there are still many problems and gaps in the stability of Poria cocos fermentation process, as well as the safety and toxicity of fermented products, which need to be improved or innovated in future research.

Cite this article

TAN Qianwen , ZOU Cunchao , HOU Chunying , LIU Bing , ZHANG Mingchen , WANG Zhaosong . Research progress of liquid fermentation and anti-tumor mechanisms of active substances from Poria cocos[J]. Food and Fermentation Industries, 2024 , 50(14) : 385 -392 . DOI: 10.13995/j.cnki.11-1802/ts.037323

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